午餐时间运动：对2型糖尿病中年男性血糖控制及氧化应激的影响
Exercise at lunchtime: effect on glycemic control and oxidative stress in middle-aged men with type 2 diabetes.
作者信息
Haxhi Jonida, Leto Gaetano, di Palumbo Alessandro Scotto, Sbriccoli Paola, Guidetti Laura, Fantini Cristina, Buzzetti Raffaella, Caporossi Daniela, Di Luigi Luigi, Sacchetti Massimo
机构信息
Department of Movement, Human and Health Sciences, University of Rome Foro Italico, Piazza Lauro de Bosis 6, Rome, Italy.
Department of Experimental Medicine, Sant'Andrea Hospital, Sapienza University of Rome, Rome, Italy.
出版信息
Eur J Appl Physiol. 2016 Mar;116(3):573-82. doi: 10.1007/s00421-015-3317-3. Epub 2015 Dec 28.
PURPOSE
Postprandial hyperglycemia and glycemic oscillations have been associated with increased oxidative stress. We sought to investigate the effect of two walking exercise protocols performed during lunchtime on glycemic control and oxidative stress in type 2 diabetic (T2D) patients.
METHODS
Nine T2D patients participated in three randomized crossover trials; a control trial (Con), with participants having a standard lunch followed by their normal daily activities and two exercise trials (ContEx and Splitex). In ContEx, subjects performed 40 min of brisk walking 40 min after lunch, whereas in SplitEx the walking exercise was divided in two 20-min isoenergetic bouts, before and 40 min after meal. 24-h glycemic control was monitored by continuous glucose monitoring. 24-h urinary levels of 8-iso PGF2ɑ were measured as a marker of oxidative stress.
RESULTS
SplitEx resulted in less time spent in moderate hyperglycemia after lunch vs ContEx (42.4 ± 38.7% vs 68.2 ± 32.7%, P = 0.04). ContEx reduced hyperglycemic time after breakfast consumed the morning after the exercise session (58.3 ± 29.6 Con vs 40.2 ± 33.4% ContEx, P = 0.02). Compared with Con, 24-h urinary isoprostanes were decreased both in ContEx (-68%, P = 0.02) and SplitEx (-63%, P = 0.04).
CONCLUSIONS
Splitting an exercise session into two bouts, pre- and post-lunch, affects mainly the glycemic response to lunch, while a single-continuous isoenergetic session exerts its effect later in the 24-h period. Both exercise modalities effectively attenuate systemic oxidative stress with similar overall benefits.
目的
餐后高血糖和血糖波动与氧化应激增加有关。我们试图研究在午餐时间进行的两种步行运动方案对2型糖尿病（T2D）患者血糖控制和氧化应激的影响。
方法
9名T2D患者参与了三项随机交叉试验；一项对照试验（Con），参与者食用标准午餐后进行日常活动，以及两项运动试验（ContEx和SplitEx）。在ContEx试验中，受试者在午餐后40分钟进行40分钟的快走，而在SplitEx试验中，步行运动分为两次20分钟的等能量运动，分别在饭前和饭后40分钟进行。通过连续血糖监测来监测24小时血糖控制情况。测量24小时尿中8-异前列腺素F2α的水平作为氧化应激的标志物。
结果
与ContEx相比，SplitEx导致午餐后中度高血糖持续时间更短（42.4±38.7%对68.2±32.7%，P = 0.04）。ContEx减少了运动后次日早晨食用早餐后的高血糖时间（Con组为58.3±29.6%，ContEx组为40.2±33.4%，P = 0.02）。与Con组相比，ContEx（-68%，P = 0.02）和SplitEx（-63%，P = 0.04）的24小时尿异前列腺素均降低。
结论
将一次运动分为午餐前和午餐后两次进行，主要影响对午餐的血糖反应，而单次连续等能量运动在24小时后期发挥作用。两种运动方式均能有效减轻全身氧化应激，总体益处相似。
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