Novak Scott P, Peiper Nicholas C, Zarkin Gary A
RTI International, Research Triangle Park, 3040 East Cornwallis Road, NC 27709, United States.
Drug Alcohol Depend. 2016 Feb 1;159:101-8. doi: 10.1016/j.drugalcdep.2015.11.039. Epub 2015 Dec 17.
This study examined poly-drug use involving the use of cannabis with nonmedical prescription pain reliever use (NMPR) and alcohol use.
Computer-assisted survey data from the National Survey on Drug Use and Health were examined. The NSDUH is an annual, cross-sectional survey of non-institutionalized citizens in the United States (ages 12+). Replicate analyses were conducted using the 2013 and 2003 survey waves.
Higher levels of cannabis use were consistently associated with more frequent consumption of prescription pain relievers, with findings replicating in both 2013 and 2003. While the prevalence of dual users declined from 2003 (2.5%) to 2013 (2.3%), the average number of days used among dual users increased by an average of 20 days over that period. These changes largely occurred among those aged 35 or older, males, whites, and non-illicit drug users. Past-year marijuana use increased by 16% (10.8-12.6%, p-value<.001) whereas NMPR decreased by 15% (4.9-4.2%, p-value<.001). The largest changes occurred after 2011. Persons using the most cannabis generally had higher levels of alcohol use relative to those using the least amount of cannabis. There was a significant increase in the prevalence of dual use between 2003 (10.2%) and 2013 (11.6%), while the prevalence of past-year alcohol use remained relatively stable.
Clinical efforts and public health interventions should consider the possible co-ingestion of cannabis with NMPR and alcohol, as concomitant use may portend negative health effects in the short and long-term.
本研究调查了大麻与非医疗处方止痛药(NMPR)及酒精同时使用的多药滥用情况。
对来自全国药物使用和健康调查的计算机辅助调查数据进行了分析。全国药物使用和健康调查是对美国非机构化公民(12岁及以上)的年度横断面调查。使用2013年和2003年的调查数据进行了重复分析。
大麻使用量较高一直与更频繁地使用处方止痛药相关,这一结果在2013年和2003年的研究中均得到了验证。虽然同时使用两种药物的人群比例从2003年的2.5%下降到了2013年的2.3%,但在此期间,同时使用两种药物的人群平均使用天数增加了20天。这些变化主要发生在35岁及以上人群、男性、白人和非非法药物使用者中。过去一年中,大麻使用量增加了16%(从10.8%增至12.6%,p值<0.001),而非医疗处方止痛药的使用量则下降了15%(从4.9%降至4.2%,p值<0.001)。最大的变化发生在2011年之后。使用大麻最多的人群相对于使用大麻最少的人群,通常酒精使用量也更高。2003年(10.2%)至2013年(11.6%)期间,同时使用两种药物的人群比例显著增加,而过去一年中酒精使用的人群比例则相对稳定。
临床工作和公共卫生干预措施应考虑大麻与非医疗处方止痛药及酒精同时使用的可能性,因为同时使用可能在短期和长期内对健康产生负面影响。