一项横断面研究，旨在评估中国绝经后女性样本中教育水平与骨质疏松症之间的关联。

A cross-sectional study to estimate associations between education level and osteoporosis in a Chinese postmenopausal women sample.

作者信息

Piao Hui-Hong, He Jiajia, Zhang Keqin, Tang Zihui

机构信息

Department of Endocrinology and Metabolism, Shanghai Tongji Hospital, School of Medicine, Tongji University Shanghai, China.

Department of Science and Tech, The People's Hospital of Mengzi Honghe, Yunnan, China.

出版信息

Int J Clin Exp Med. 2015 Nov 15;8(11):21014-23. eCollection 2015.

PMID:26885032

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4723877/

Abstract

BACKGROUND

Our research aims to investigate the associations between education level and osteoporosis (OP) in Chinese postmenopausal women.

METHODS

A large-scale, community-based, cross-sectional study was conducted to examine the associations between education level and OP. A self-reported questionnaire was used to access the demographical information and medical history of the participants. A total of 1905 postmenopausal women were available for data analysis in this study. Multiple regression models controlling for confounding factors to include education level were performed to investigate the relationship with OP.

RESULTS

The prevalence of OP was 28.29% in our study sample. Multivariate linear regression analyses adjusted for relevant potential confounding factors detected significant associations between education level and T-score (β = 0.025, P-value = 0.095, 95% CI: -0.004-0.055 for model 1; and β = 0.092, P-value = 0.032, 95% CI: 0.008-0.175 for model 2). Multivariate logistic regression analyses detected significant associations between education level and OP in model 1 (P-value = 0.070 for model 1, Table 5), while no significant associations was reported in model 2 (P value = 0.131). In participants with high education levels, the OR for OP was 0.914 (95% CI: 0.830-1.007).

CONCLUSION

The findings indicated that education level was independently and significantly associated with OP. The prevalence of OP was more frequent in Chinese postmenopausal women with low educational status.

摘要

背景

我们的研究旨在调查中国绝经后女性教育水平与骨质疏松症（OP）之间的关联。

方法

开展了一项大规模、基于社区的横断面研究，以检验教育水平与OP之间的关联。使用一份自填式问卷来获取参与者的人口统计学信息和病史。本研究共有1905名绝经后女性可供数据分析。进行了控制混杂因素（包括教育水平）的多元回归模型，以研究与OP的关系。

结果

在我们的研究样本中，OP的患病率为28.29%。对相关潜在混杂因素进行调整后的多元线性回归分析发现，教育水平与T值之间存在显著关联（模型1：β = 0.025，P值 = 0.095，95%置信区间：-0.004 - 0.055；模型2：β = 0.092，P值 = 0.032，95%置信区间：0.008 - 0.175）。多元逻辑回归分析在模型1中发现教育水平与OP之间存在显著关联（模型1的P值 = 0.070，表5），而在模型2中未报告显著关联（P值 = 0.131）。在高教育水平的参与者中，OP的比值比为0.914（95%置信区间：0.830 - 1.007）。