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[接触性过敏性胃炎:金属过敏的罕见表现]

[Contact allergic gastritis : Rare manifestation of a metal allergy].

作者信息

Pföhler C, Vogt T, Müller C S L

机构信息

Klinik für Dermatologie, Venerologie und Allergologie, Universitätsklinikum des Saarlandes, 66421, Homburg/Saar, Deutschland.

出版信息

Hautarzt. 2016 May;67(5):359-64. doi: 10.1007/s00105-016-3773-7.

Abstract

Only a few cases of contact allergic gastritis in patients with nickel allergy have been reported in the literature. We report a case of probable contact-allergic gastritis in a 46-year-old woman. Clinical examination revealed lichenoid mucosal lesions of the gums adjacent to a bridge and crowns that had been implanted several weeks previously. Since implantation, the patient suffered from gastrointestinal complaints including stomach pain. Gastroscopy and histological investigation of stomach biopsies showed eosinophilic gastritis. Patch testing done under the diagnosis of contact allergic stomatitis showed positive reactions to gold sodium thiosulphate, manganese (II) chloride, nickel (II) sulphate, palladium chloride, vanadium (III) chloride, zirconium (IV) chloride, and fragrances. The crowns and the bridge contained gold, palladium, and zirconium, hence they were replaced by titan-based dentition. Shortly after replacing the artificial dentition, all gastrointestinal symptoms resolved spontaneously without further treatment. Delayed-type allergy to components in the artificial dentition seem to have caused the gastritis.

摘要

文献中仅报道了少数镍过敏患者发生接触性变应性胃炎的病例。我们报告一例46岁女性可能患有接触性变应性胃炎的病例。临床检查发现,在数周前植入的牙桥和牙冠附近的牙龈出现苔藓样黏膜病变。自植入以来,患者一直有胃肠道不适,包括胃痛。胃镜检查和胃活检的组织学检查显示为嗜酸性胃炎。在接触性变应性口腔炎的诊断下进行的斑贴试验显示,对硫代硫酸金钠、氯化锰(II)、硫酸镍(II)、氯化钯、氯化钒(III)、氯化锆(IV)和香料呈阳性反应。牙冠和牙桥含有金、钯和锆,因此用钛基牙列进行了替换。更换人工牙列后不久,所有胃肠道症状未经进一步治疗即自行缓解。对人工牙列成分的迟发型过敏似乎导致了胃炎。

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