基于二维黑磷纳米片的场效应晶体管生物传感器。
Field-effect transistor biosensors with two-dimensional black phosphorus nanosheets.
机构信息
Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N. Cramer Street, Milwaukee, WI 53211, USA.
Department of Mechanical Engineering, University of Wisconsin-Milwaukee, 3200 N. Cramer Street, Milwaukee, WI 53211, USA; State Key Laboratory of Pollution Control and Resource Reuse, School of Environmental Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, PR China.
出版信息
Biosens Bioelectron. 2017 Mar 15;89(Pt 1):505-510. doi: 10.1016/j.bios.2016.03.059. Epub 2016 Mar 26.
A black phosphorous (BP)-based field-effect transistor (FET) biosensor was fabricated by using few-layer BP nanosheets labeled with gold nanoparticle-antibody conjugates. BP nanosheets were mechanically exfoliated and used as the sensing/conducting channel in the FET, with an AlO thin film as the dielectric layer for surface passivation. Antibody probes were conjugated with gold nanoparticles that were sputtered on the BP through surface functionalization. The sensor response was measured by the change in the BP's electrical resistance after antigens were introduced. The adsorbed antigens through specific antigen-antibody binding interactions induced a gate potential, thereby changing the drain-source current. The as-produced BP biosensor showed both high sensitivity (lower limit of detection ~10ng/ml) and selectivity towards human immunoglobulin G. Results from this study demonstrate the outstanding performance of BP as a sensing channel for FET biosensor applications.
基于黑磷（BP）的场效应晶体管（FET）生物传感器是通过使用标记有金纳米粒子-抗体缀合物的少层 BP 纳米片制造的。BP 纳米片通过机械剥落并用作用于 FET 的传感/传导通道，而 AlO 薄膜用作表面钝化的介电层。抗体探针通过表面功能化与溅射在 BP 上的金纳米粒子偶联。通过引入抗原后 BP 电阻的变化来测量传感器响应。通过特定的抗原-抗体结合相互作用吸附的抗原诱导栅极电势，从而改变漏源电流。所制备的 BP 生物传感器对人免疫球蛋白 G 表现出高灵敏度（检测限约为 10ng/ml）和选择性。这项研究的结果表明，BP 作为 FET 生物传感器应用的传感通道具有出色的性能。
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