Yi Rui, Li Yao, Wang Fei-Liang, Miao Gang, Qi Ruo-Mei, Zhao Yan-Yang
Rui Yi, Ruo-Mei Qi, Yan-Yang Zhao, the Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
World J Gastrointest Oncol. 2016 Apr 15;8(4):330-40. doi: 10.4251/wjgo.v8.i4.330.
MicroRNAs (miRNAs) are key regulators involved in various tumors. They regulate cell cycle, apoptosis and cancer stemness, metastasis and chemoresistance by controlling their target gene expressions. Here, we mainly discuss the potential uses of miRNAs in colorectal cancer (CRC) diagnosis. We also shed light on the important corresponding miRNA targets and on the major regulators of miRNAs. Furthermore, we discuss miRNA activity in assessing the prognosis and recurrence of CRC as well as in modulating responsiveness to chemotherapy. Based on the various pro-oncogenic/anti-oncogenic roles of miRNAs, the advantages of a therapeutic strategy based on the delivery of miRNA mimics are also mentioned. Together, miRNA seems to be an excellent tool for effectively monitoring and targeting CRC.
微小RNA（miRNA）是参与多种肿瘤的关键调节因子。它们通过控制靶基因表达来调节细胞周期、细胞凋亡、癌症干性、转移和化疗耐药性。在此，我们主要讨论miRNA在结直肠癌（CRC）诊断中的潜在用途。我们还阐明了重要的相应miRNA靶标以及miRNA的主要调节因子。此外，我们讨论了miRNA在评估CRC预后和复发以及调节化疗反应性方面的活性。基于miRNA的各种促癌/抑癌作用，还提到了基于miRNA模拟物递送的治疗策略的优势。总之，miRNA似乎是有效监测和靶向CRC的优秀工具。
