Leylabadlo Hamed Ebrahimzadeh, Yekani Mina, Ghotaslou Reza
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz 51636-39888, Iran.
Department of Microbiology, School of Medicine, Tabriz University of Medical Sciences, Tabriz 51664-14766, Iran.
Biomed Rep. 2016 May;4(5):601-604. doi: 10.3892/br.2016.634. Epub 2016 Mar 18.
The () outer membrane protein (HopQ) of is one of the proteins involved in bacterial adherence to gastric mucosa and has been suggested to have a role in the virulence of . The aim of the present study was to determine the association between virulence types I and II genotypes and patients with different gastrointestinal diseases. A polymerase chain reaction-based assay was used to determine the presence of type I and type II genes in 88 strains isolated from -infected patients. Of the total 88 isolates, type I and type II alleles were detected in 52 (59.1%) and 36 (40.9%), respectively. A significant association was found between type I gene and gastric cancer [odds ratio, 2.3; 95% confidence interval (CI), 1.3-4.1] and gastric ulcers (odds ratio, 2.5; 95% CI, 1.4-4.3). A significant association was also identified between the type II gene and gastric cancer (odds ratio, 2.4; 95% CI, 1.1-3.0). The association between type I and type II genotypes and clinical status suggest that these genes may be helpful in the universal prediction of specific disease risks.
幽门螺杆菌的（）外膜蛋白（HopQ）是参与细菌黏附胃黏膜的蛋白质之一，并且已表明其在幽门螺杆菌的毒力方面发挥作用。本研究的目的是确定幽门螺杆菌毒力I型和II型基因型与不同胃肠道疾病患者之间的关联。基于聚合酶链反应的检测方法用于确定从幽门螺杆菌感染患者中分离出的88株幽门螺杆菌菌株中I型和II型基因的存在情况。在总共88株分离株中，分别在52株（59.1%）和36株（40.9%）中检测到I型和II型等位基因。发现I型幽门螺杆菌基因与胃癌[比值比，2.3；95%置信区间（CI），1.3 - 4.1]和胃溃疡（比值比，2.5；95% CI，1.4 - 4.3）之间存在显著关联。还确定II型幽门螺杆菌基因与胃癌之间存在显著关联（比值比，2.4；95% CI，1.1 - 3.0）。幽门螺杆菌I型和II型基因型与临床状况之间的关联表明，这些基因可能有助于普遍预测特定疾病风险。
