Brindal Emily, Hendrie Gilly A, Taylor Pennie, Freyne Jill, Noakes Manny
Food and Nutrition, Commonwealth Scientific and Industrial Research Organization (CSIRO), PO Box 10041, Adelaide, South Australia 5000, Australia.
Health and Biosecurity, CSIRO, GPO Box 76, Epping, New South Wales 1710, Australia.
Nutrients. 2016 May 4;8(5):265. doi: 10.3390/nu8050265.
Our aim was to design and evaluate a weight-loss program, including a partial meal replacement program, point-of-care testing and face-to-face and smartphone app support, appropriate for delivery in a community pharmacy setting. Overweight or obese adults (n = 146, 71.2% female, 48.18 ± 11.75 years old) were recruited to participate in a 24-week weight loss study and randomised to two app conditions. The dietary intervention was consistent regardless of app. Twelve weeks of clinic appointments with a trained consultant were followed by only app support for an additional 12 weeks. By week 24, retention was 57.5%. There were no differences between app conditions. Based on a cohort analysis of the trial, the mean decrease in weight from baseline to week 24 was 6.43 ± 1.06 kg for males (p < 0.001) and 5.66 ± 0.70 kg for females (p < 0.001). Mixed models also revealed decreases for LDL Cholesterol (-0.13 ± 0.08 mmol/L, nonsignificant), triglycerides (-0.08 ± 0.05 mmol/L, nonsignificant) and an increase in HDL cholesterol (+0.08 ± 0.04 mmol/L, ns) were not significant by week 24. Blood glucose (-0.23 ± 0.08 mmol/L, p = 0.040) and blood pressure (Systolic blood pressure -5.77 ± 1.21 Hg/mm, p < 0.001) were significantly lower at week 24 compared to baseline. Weight loss self-efficacy increased and remained significantly higher than baseline at week 24 (16.85 ± 2.93, p < 0.001). Overall, the program supported participants and was successful in achieving significant weight loss and improvements in health outcomes over 24 weeks.
我们的目标是设计并评估一项减肥计划，该计划包括部分代餐计划、即时检测以及面对面和智能手机应用程序支持，适合在社区药房环境中实施。招募了超重或肥胖成年人（n = 146，女性占71.2%，年龄48.18 ± 11.75岁）参与一项为期24周的减肥研究，并随机分为两种应用程序条件组。无论应用程序如何，饮食干预都是一致的。在与经过培训的顾问进行12周的门诊预约后，仅通过应用程序支持再持续12周。到第24周时，保留率为57.5%。两种应用程序条件组之间没有差异。基于该试验的队列分析，从基线到第24周，男性体重平均下降6.43 ± 1.06千克（p < 0.001），女性体重平均下降5.66 ± 0.70千克（p < 0.001）。混合模型还显示，到第24周时，低密度脂蛋白胆固醇（-0.13 ± 0.08毫摩尔/升，无显著差异）、甘油三酯（-0.08 ± 0.05毫摩尔/升，无显著差异）下降，高密度脂蛋白胆固醇升高（+0.08 ± 0.04毫摩尔/升，无显著差异）均无显著意义。与基线相比，第24周时血糖（-0.23 ± 0.08毫摩尔/升，p = 0.040）和血压（收缩压-5.77 ± 1.21毫米汞柱，p < 0.001）显著降低。减肥自我效能感增强，在第24周时仍显著高于基线（16.85 ± 2.93，p < 0.001）。总体而言，该计划为参与者提供了支持，并在为期24周的时间里成功实现了显著的体重减轻和健康结果改善。
