一组美国空乘人员中神经退行性疾病导致的死亡率。
Mortality from neurodegenerative diseases in a cohort of US flight attendants.
作者信息
Pinkerton Lynne E, Hein Misty J, Grajewski Barbara, Kamel Freya
机构信息
Industrywide Studies Branch, Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Cincinnati, Ohio.
CACI, Inc., Cincinnati, Ohio.
出版信息
Am J Ind Med. 2016 Jul;59(7):532-7. doi: 10.1002/ajim.22608. Epub 2016 May 17.
BACKGROUND
Concern exists about the potential chronic neurological effects among aircrew of exposure to chemical contaminants from engine oil in aircraft cabin air. We evaluated mortality from neurodegenerative diseases among 11,311 former US flight attendants.
METHODS
Vital status was ascertained through 2007, and life table analyses were conducted to obtain standardized mortality ratios (SMRs).
RESULTS
Amyotrophic lateral sclerosis (ALS) mortality was over twice as high in the cohort as in the US general population, based on nine observed ALS deaths. There was no clear pattern in risk when SMRs for ALS were stratified by exposure duration. Mortality from other neurodegenerative diseases was not elevated.
CONCLUSIONS
Our findings are limited due to small numbers of observed deaths and reliance on mortality data, but suggest that flight attendants may have an increased risk of ALS. Additional research is needed. Am. J. Ind. Med. 59:532-537, 2016. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.
背景
飞机机舱空气中的发动机油化学污染物暴露对机组人员潜在的慢性神经影响令人担忧。我们评估了11311名美国前空乘人员的神经退行性疾病死亡率。
方法
通过2007年确定生命状态，并进行生命表分析以获得标准化死亡率（SMR）。
结果
基于9例观察到的肌萎缩侧索硬化症（ALS）死亡病例，该队列中ALS死亡率是美国普通人群的两倍多。当按暴露持续时间对ALS的SMR进行分层时，风险没有明显模式。其他神经退行性疾病的死亡率没有升高。
结论
由于观察到的死亡病例数量较少且依赖死亡率数据，我们的研究结果有限，但表明空乘人员患ALS的风险可能增加。需要进一步研究。《美国工业医学杂志》59:532 - 537，2016年。2016年发表。本文是美国政府作品，在美国属于公共领域。
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