Peric Marina, Peric Stojan, Rapajic Nada, Dobricic Valerija, Savic-Pavicevic Dusanka, Nesic Ivana, Radojicic Svetlana, Novakovic Ivana, Lavrnic Dragana, Rakocevic-Stojanovic Vidosava
Mother and Child Health Care Institute, Belgrade, Serbia;
Neurology Clinic, Clinical Center of Serbia, School of Medicine, University of Belgrade, Belgrade, Serbia;
Acta Myol. 2015 Dec;34(2-3):126-32.
To analyze the frequency and intensity of pain and its association with different characteristics of patients with myotonic dystrophy type 1 (DM1) and type 2 (DM2), 52 adult genetically confirmed DM1 and 44 DM2 patients completed the Brief Pain Inventory questionnaire (BPI). Frequency and average intensity of pain on numerical rating scale (0-10) were similar in DM1 and DM2 (88% vs. 86% and 4.6 ± 2.3 vs. 4.2 ± 1.8, respectively, p > 0.05). In DM1, average pain intensity showed strong association with longer duration of disease and inverse relation with cognition. In DM2, average pain intensity showed association with female gender and emotions. Average pain intensity correlated with Individualized Neuromuscular Quality of Life (INQoL) total score in both DM1 (rho = +0.30, p < 0.05) and DM2 patients (rho = +0.61, p < 0.01). In conclusion, the majority of DM1 and DM2 patients have mild to moderate pain. Our results open new opportunities for behavioral and cognitive interventions.
为分析1型强直性肌营养不良（DM1）和2型强直性肌营养不良（DM2）患者疼痛的频率、强度及其与不同特征的关联，52例经基因确诊的成年DM1患者和44例DM2患者完成了简明疼痛问卷（BPI）。DM1和DM2患者在数字评分量表（0 - 10）上的疼痛频率和平均强度相似（分别为88%对86%，4.6±2.3对4.2±1.8，p>0.05）。在DM1中，平均疼痛强度与疾病持续时间较长呈强关联，与认知呈负相关。在DM2中，平均疼痛强度与女性性别和情绪有关。在DM1（rho = +0.30，p<0.05）和DM2患者（rho = +0.61，p<0.01）中，平均疼痛强度均与个体化神经肌肉生活质量（INQoL）总分相关。总之，大多数DM1和DM2患者有轻至中度疼痛。我们的结果为行为和认知干预提供了新机会。
