Ott J
Department of Psychiatry, Columbia University, New York, NY 10032.
Genet Epidemiol. 1989;6(1):127-30. doi: 10.1002/gepi.1370060124.
In the haplotype relative risk (HRR) statistic (Rubinstein et al.: Human Immunol 3:384 [abstract], 1981), a disease sample is constructed along with its own internal control by comparing those marker alleles passed from the parents to an affected child with the other parental marker alleles not transmitted. Based on the conditional parental genotype distribution given that they have an affected child, statistical properties of the HRR statistic are derived. It is shown that the HRR is different from 1 only when allelic association is present and the recombination fraction is different from 1/2. Transmitted and nontransmitted marker alleles are shown to be statistically independent only in the absence of either allelic association or recombination.
在单倍型相对风险（HRR）统计量中（鲁宾斯坦等人：《人类免疫学》3:384[摘要]，1981年），通过将从父母传递给患病子女的那些标记等位基因与未传递的其他父母标记等位基因进行比较，构建一个疾病样本及其自身的内部对照。基于已知他们有一个患病子女的条件下父母基因型分布，推导了HRR统计量的统计特性。结果表明，只有当存在等位基因关联且重组率不同于1/2时，HRR才不同于1。只有在不存在等位基因关联或重组的情况下，传递和未传递的标记等位基因才在统计上独立。
