Cronin Jeneva A, Wu Jing, Collins Kelly L, Sarma Devapratim, Rao Rajesh P N, Ojemann Jeffrey G, Olson Jared D
IEEE Trans Haptics. 2016 Oct-Dec;9(4):515-522. doi: 10.1109/TOH.2016.2591952. Epub 2016 Jul 18.
Cortical stimulation through electrocorticographic (ECoG) electrodes is a potential method for providing sensory feedback in future prosthetic and rehabilitative applications. Here, we evaluate human subjects' ability to continuously modulate their motor behavior based on feedback from direct surface stimulation of the somatosensory cortex. Subjects wore a dataglove that measured their hand aperture position and received one of three stimuli over the hand sensory cortex based on their current hand position as compared to a target aperture position. Using cortical stimulation feedback, subjects adjusted their hand aperture to move towards the target aperture region. One subject was able to achieve accuracies and R values well above chance (best performance: R = 0.93; accuracy = 0.76/1). Performance dropped during the catch trial (same stimulus independent of the position) to below chance levels, suggesting that the subject had been using the varied sensory feedback to modulate their motor behavior. To our knowledge, this study represents one of the first demonstrations of using direct cortical surface stimulation of the human sensory cortex to perform a motor task, and is a first step towards developing closed-loop human sensorimotor brain-computer interfaces.
通过皮层脑电图（ECoG）电极进行皮层刺激是一种在未来假肢和康复应用中提供感觉反馈的潜在方法。在此，我们评估了人类受试者基于体感皮层直接表面刺激的反馈持续调节其运动行为的能力。受试者佩戴一个测量其手部开度位置的数据手套，并根据其当前手部位置与目标开度位置相比，在手部感觉皮层上接受三种刺激之一。利用皮层刺激反馈，受试者调整其手部开度以朝着目标开度区域移动。一名受试者能够达到远高于随机水平的准确率和R值（最佳表现：R = 0.93；准确率 = 0.7 / 1）。在捕捉试验期间（无论位置如何都给予相同刺激），表现降至随机水平以下，这表明受试者一直在利用变化的感觉反馈来调节其运动行为。据我们所知，本研究是利用对人类感觉皮层的直接皮层表面刺激来执行运动任务的首批示范之一，并且是朝着开发闭环人类感觉运动脑机接口迈出的第一步。
