Wang Tian-Bao, Hu Bao-Guang, Liu Da-Wei, Gao Zhen-Hua, Shi Han-Ping, Dong Wen-Guang
Department of Surgery, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, P.R. China.
Department of Gastrointestinal Surgery, The Affiliated Hospital, Binzhou Medical College, Binzhou, Shandong 256603, P.R. China.
Oncol Lett. 2016 Aug;12(2):928-932. doi: 10.3892/ol.2016.4720. Epub 2016 Jun 15.
Sclerosing angiomatoid nodular transformation (SANT) is a rare benign splenic vascular lesion. Since it was first defined in 2004, a total of 132 cases of SANT have been reported in ~50 studies in the English literature. However, it remains difficult to form a definitive pre-operative differential diagnosis of SANT compared with other splenic tumors or malignant lesions. The present study reports a pathologically proven case of SANT in a 29-year-old man who initially presented with left upper quadrant and back discomfort. The study also provides a review of the current knowledge on the condition, including the clinical profile, imaging features, cytological features, differential diagnosis and treatment of SANT. The most important distinguishing features of SANT are its typical vascular character and lack of other features that are typical of a granuloma. A splenectomy is required and the diagnosis is based on pathological analysis.
硬化性血管瘤样结节性转化（SANT）是一种罕见的脾脏良性血管病变。自2004年首次定义以来，英文文献中约50项研究共报道了132例SANT病例。然而，与其他脾脏肿瘤或恶性病变相比，术前对SANT进行明确的鉴别诊断仍然困难。本研究报告了一例经病理证实的SANT病例，患者为一名29岁男性，最初表现为左上腹和背部不适。该研究还对目前关于该疾病的知识进行了综述，包括SANT的临床特征、影像学特征、细胞学特征、鉴别诊断和治疗。SANT最重要的鉴别特征是其典型的血管特征以及缺乏肉芽肿的其他典型特征。需要进行脾切除术，诊断基于病理分析。
