• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

对古代近东地区农业起源的基因组学洞察。

Genomic insights into the origin of farming in the ancient Near East.

作者信息

Lazaridis Iosif, Nadel Dani, Rollefson Gary, Merrett Deborah C, Rohland Nadin, Mallick Swapan, Fernandes Daniel, Novak Mario, Gamarra Beatriz, Sirak Kendra, Connell Sarah, Stewardson Kristin, Harney Eadaoin, Fu Qiaomei, Gonzalez-Fortes Gloria, Jones Eppie R, Roodenberg Songül Alpaslan, Lengyel György, Bocquentin Fanny, Gasparian Boris, Monge Janet M, Gregg Michael, Eshed Vered, Mizrahi Ahuva-Sivan, Meiklejohn Christopher, Gerritsen Fokke, Bejenaru Luminita, Blüher Matthias, Campbell Archie, Cavalleri Gianpiero, Comas David, Froguel Philippe, Gilbert Edmund, Kerr Shona M, Kovacs Peter, Krause Johannes, McGettigan Darren, Merrigan Michael, Merriwether D Andrew, O'Reilly Seamus, Richards Martin B, Semino Ornella, Shamoon-Pour Michel, Stefanescu Gheorghe, Stumvoll Michael, Tönjes Anke, Torroni Antonio, Wilson James F, Yengo Loic, Hovhannisyan Nelli A, Patterson Nick, Pinhasi Ron, Reich David

出版信息

Nature. 2016 Aug 25;536(7617):419-24. doi: 10.1038/nature19310. Epub 2016 Jul 25.

DOI:10.1038/nature19310
PMID:27459054
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5003663/
Abstract

We report genome-wide ancient DNA from 44 ancient Near Easterners ranging in time between ~12,000 and 1,400 bc, from Natufian hunter-gatherers to Bronze Age farmers. We show that the earliest populations of the Near East derived around half their ancestry from a 'Basal Eurasian' lineage that had little if any Neanderthal admixture and that separated from other non-African lineages before their separation from each other. The first farmers of the southern Levant (Israel and Jordan) and Zagros Mountains (Iran) were strongly genetically differentiated, and each descended from local hunter-gatherers. By the time of the Bronze Age, these two populations and Anatolian-related farmers had mixed with each other and with the hunter-gatherers of Europe to greatly reduce genetic differentiation. The impact of the Near Eastern farmers extended beyond the Near East: farmers related to those of Anatolia spread westward into Europe; farmers related to those of the Levant spread southward into East Africa; farmers related to those of Iran spread northward into the Eurasian steppe; and people related to both the early farmers of Iran and to the pastoralists of the Eurasian steppe spread eastward into South Asia.

摘要

我们报告了44位古代近东人的全基因组古DNA，时间跨度约为公元前12000年至1400年，涵盖从纳图夫狩猎采集者到青铜时代农民的群体。我们发现，近东最早的人群约一半的血统来自一个“基底欧亚人”谱系，该谱系几乎没有尼安德特人混血，并且在其他非非洲谱系彼此分离之前就已与它们分道扬镳。黎凡特南部（以色列和约旦）和扎格罗斯山脉（伊朗）的首批农民在基因上有很大差异，且各自都起源于当地的狩猎采集者。到青铜时代，这两个人群以及与安纳托利亚相关的农民相互融合，并与欧洲的狩猎采集者混合，从而大大减少了基因差异。近东农民的影响超出了近东地区：与安纳托利亚农民相关的人群向西扩散到欧洲；与黎凡特农民相关的人群向南扩散到东非；与伊朗农民相关的人群向北扩散到欧亚草原；与伊朗早期农民和欧亚草原牧民都相关的人群向东扩散到南亚。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/8eda07abd5b3/nihms-804247-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/3f254de33501/nihms-804247-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/bf26213accf3/nihms-804247-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/f6f9f20b6a7d/nihms-804247-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/a570413ba050/nihms-804247-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/9202df5b9721/nihms-804247-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/9223aadf9e19/nihms-804247-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/4ddc9c4e3f92/nihms-804247-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/56050daafcc0/nihms-804247-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/2ddf0548bb2e/nihms-804247-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/b5d1877d7513/nihms-804247-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/744609706ad7/nihms-804247-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/8eda07abd5b3/nihms-804247-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/3f254de33501/nihms-804247-f0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/bf26213accf3/nihms-804247-f0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/f6f9f20b6a7d/nihms-804247-f0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/a570413ba050/nihms-804247-f0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/9202df5b9721/nihms-804247-f0009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/9223aadf9e19/nihms-804247-f0010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/4ddc9c4e3f92/nihms-804247-f0011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/56050daafcc0/nihms-804247-f0012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/2ddf0548bb2e/nihms-804247-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/b5d1877d7513/nihms-804247-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/744609706ad7/nihms-804247-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/eadb/5003663/8eda07abd5b3/nihms-804247-f0004.jpg

相似文献

1
Genomic insights into the origin of farming in the ancient Near East.对古代近东地区农业起源的基因组学洞察。
Nature. 2016 Aug 25;536(7617):419-24. doi: 10.1038/nature19310. Epub 2016 Jul 25.
2
The genomic history of southeastern Europe.东南欧的基因组历史。
Nature. 2018 Mar 8;555(7695):197-203. doi: 10.1038/nature25778. Epub 2018 Feb 21.
3
Late Pleistocene human genome suggests a local origin for the first farmers of central Anatolia.更新世晚期人类基因组表明，安纳托利亚中部的第一批农民起源于当地。
Nat Commun. 2019 Mar 19;10(1):1218. doi: 10.1038/s41467-019-09209-7.
4
Archaeogenomic analysis of the first steps of Neolithization in Anatolia and the Aegean.安纳托利亚和爱琴海新石器化初期的考古基因组分析。
Proc Biol Sci. 2017 Nov 29;284(1867). doi: 10.1098/rspb.2017.2064.
5
A genomic Neolithic time transect of hunter-farmer admixture in central Poland.波兰中部新石器时代狩猎采集者混合的基因组时间剖面。
Sci Rep. 2018 Oct 5;8(1):14879. doi: 10.1038/s41598-018-33067-w.
6
Extensive Farming in Estonia Started through a Sex-Biased Migration from the Steppe.爱沙尼亚的大规模农业始于草原地区性别偏向性的移民。
Curr Biol. 2017 Jul 24;27(14):2185-2193.e6. doi: 10.1016/j.cub.2017.06.022. Epub 2017 Jul 14.
7
The rise and transformation of Bronze Age pastoralists in the Caucasus.青铜时代高加索牧民的兴起与转型。
Nature. 2024 Nov;635(8040):917-925. doi: 10.1038/s41586-024-08113-5. Epub 2024 Oct 30.
8
Genomic insights into the formation of human populations in East Asia.东亚人群形成的基因组学见解。
Nature. 2021 Mar;591(7850):413-419. doi: 10.1038/s41586-021-03336-2. Epub 2021 Feb 22.
9
Genetic Continuity of Bronze Age Ancestry with Increased Steppe-Related Ancestry in Late Iron Age Uzbekistan.乌兹别克斯坦晚铁器时代具有增加的草原相关祖先的青铜时代祖先的遗传连续性。
Mol Biol Evol. 2021 Oct 27;38(11):4908-4917. doi: 10.1093/molbev/msab216.
10
The evolutionary history of human populations in Europe.人类在欧洲的种群进化史。
Curr Opin Genet Dev. 2018 Dec;53:21-27. doi: 10.1016/j.gde.2018.06.007. Epub 2018 Jun 28.

引用本文的文献

1
Ancient genomes provide evidence of demographic shift to Slavic-associated groups in Moravia.古代基因组为摩拉维亚地区向与斯拉夫人相关群体的人口结构转变提供了证据。
Genome Biol. 2025 Sep 3;26(1):259. doi: 10.1186/s13059-025-03700-9.
2
Ancient DNA connects large-scale migration with the spread of Slavs.古代DNA将大规模迁徙与斯拉夫人的扩张联系起来。
Nature. 2025 Sep 3. doi: 10.1038/s41586-025-09437-6.
3
Bone Adhered Sediments as a Source of Target and Environmental DNA and Proteins.作为目标DNA、环境DNA和蛋白质来源的骨附着沉积物

本文引用的文献

1
The genetic history of Ice Age Europe.冰河时代欧洲的基因史。
Nature. 2016 Jun 9;534(7606):200-5. doi: 10.1038/nature17993. Epub 2016 May 2.
2
Genome-wide patterns of selection in 230 ancient Eurasians.230名古代欧亚人的全基因组选择模式
Nature. 2015 Dec 24;528(7583):499-503. doi: 10.1038/nature16152. Epub 2015 Nov 23.
3
Upper Palaeolithic genomes reveal deep roots of modern Eurasians.旧石器时代晚期基因组揭示了现代欧亚人的深厚根源。
Mol Biol Evol. 2025 Sep 1;42(9). doi: 10.1093/molbev/msaf202.
4
Modeling the European Neolithic expansion suggests predominant within-group mating and limited cultural transmission.对欧洲新石器时代扩张的建模表明，群体内交配占主导，文化传播有限。
Nat Commun. 2025 Aug 25;16(1):7905. doi: 10.1038/s41467-025-63172-0.
5
The AADR Visualizer: An ArcGIS Online Visualizer for ancient human DNA from the Allen Ancient DNA Resource.美国牙科研究协会可视化工具：一种用于来自艾伦古代DNA资源的古代人类DNA的ArcGIS在线可视化工具。
Bioinformatics. 2025 Aug 18;5(1). doi: 10.1093/bioadv/vbaf199.
6
The genetic history of Portugal over the past 5,000 years.葡萄牙过去5000年的基因历史。
Genome Biol. 2025 Aug 18;26(1):248. doi: 10.1186/s13059-025-03707-2.
7
A draft UAE-based Arab pangenome reference.一份基于阿联酋的阿拉伯泛基因组参考草案。
Nat Commun. 2025 Jul 24;16(1):6747. doi: 10.1038/s41467-025-61645-w.
8
Genetic history of Scythia.斯基泰人的遗传史。
Sci Adv. 2025 Jul 25;11(30):eads8179. doi: 10.1126/sciadv.ads8179. Epub 2025 Jul 23.
9
Genetic transitions in the Neolithic and Bronze Age at Mas d'en Boixos (Catalonia, Spain).西班牙加泰罗尼亚地区马斯德恩博伊克斯新石器时代和青铜时代的基因转变
iScience. 2025 Jun 11;28(7):112871. doi: 10.1016/j.isci.2025.112871. eCollection 2025 Jul 18.
10
The genomic footprints of migration: how ancient DNA reveals our history of mobility.迁徙的基因组印记：古代DNA如何揭示我们的迁徙历史。
Genome Biol. 2025 Jul 16;26(1):206. doi: 10.1186/s13059-025-03664-w.
Nat Commun. 2015 Nov 16;6:8912. doi: 10.1038/ncomms9912.
4
Ancient Ethiopian genome reveals extensive Eurasian admixture throughout the African continent.古埃塞俄比亚人基因组揭示了整个非洲大陆广泛的欧亚人群混合。
Science. 2015 Nov 13;350(6262):820-2. doi: 10.1126/science.aad2879. Epub 2015 Oct 8.
5
Ancient genomes link early farmers from Atapuerca in Spain to modern-day Basques.古代基因组将西班牙阿塔普埃尔卡的早期农民与现代巴斯克人联系起来。
Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):11917-22. doi: 10.1073/pnas.1509851112. Epub 2015 Sep 8.
6
A Common Genetic Origin for Early Farmers from Mediterranean Cardial and Central European LBK Cultures.地中海卡迪尔文化和中欧线性陶文化早期农民的共同遗传起源。
Mol Biol Evol. 2015 Dec;32(12):3132-42. doi: 10.1093/molbev/msv181. Epub 2015 Sep 2.
7
Reducing microbial and human contamination in DNA extractions from ancient bones and teeth.减少从古代骨骼和牙齿中提取DNA时的微生物和人类污染。
Biotechniques. 2015 Aug 1;59(2):87-93. doi: 10.2144/000114320. eCollection 2015 Aug.
8
Global diversity, population stratification, and selection of human copy-number variation.人类拷贝数变异的全球多样性、群体分层及选择
Science. 2015 Sep 11;349(6253):aab3761. doi: 10.1126/science.aab3761. Epub 2015 Aug 6.
9
An early modern human from Romania with a recent Neanderthal ancestor.一名来自罗马尼亚的早期现代人，拥有较近的尼安德特人祖先。
Nature. 2015 Aug 13;524(7564):216-9. doi: 10.1038/nature14558. Epub 2015 Jun 22.
10
Optimal Ancient DNA Yields from the Inner Ear Part of the Human Petrous Bone.从人类颞骨岩部内耳部分获取的最佳古代DNA产量。
PLoS One. 2015 Jun 18;10(6):e0129102. doi: 10.1371/journal.pone.0129102. eCollection 2015.