Sorice Sarah, Rustad Kristine C, Li Alexander Y, Gurtner Geoffrey C
Stanford, Calif.
From the Division of Plastic Surgery, Department of Surgery, Stanford University.
Plast Reconstr Surg. 2016 Sep;138(3 Suppl):31S-41S. doi: 10.1097/PRS.0000000000002646.
Chronic wounds present unique challenges for healthcare providers as they place patients at increased risk for various morbidities and mortality. Advances in wound care technology have expanded the treatment options available for wound management, but few products fully address the underlying core deficiencies responsible for the development of poorly healing wounds. In the future, addressing these derangements will undoubtedly play a key role in the treatment of these patients. Broad enthusiasm has surrounded the field of stem cell biology, which has shown great promise in repairing damaged tissues across numerous disease phenotypes.
In this review, we provide a comprehensive review of the literature and evaluate the present landscape of wound therapeutics while discussing the rationales and allure behind stem cell-based products. We further propose 2 challenges that remain as new stem cell-based therapies are being developed and as this technology moves toward clinical translation.
Given the relatively young age of this newer technology in wound healing, numerous challenges continue to surround its effective use including identifying the ideal population of stem cells to use and determining the optimal cell delivery method. However, significant forward progress has been made, with several clinical trials beginning to demonstrate reliable clinical benefit.
The upward trajectory of stem cell technologies provides an exciting opportunity to positively impact patient outcomes through the controlled application of regenerative cell-based therapy.
慢性伤口给医疗服务提供者带来了独特的挑战，因为它们会增加患者出现各种疾病和死亡的风险。伤口护理技术的进步扩大了伤口管理的可用治疗选择，但很少有产品能完全解决导致伤口愈合不良的潜在核心缺陷。未来，解决这些紊乱问题无疑将在这些患者的治疗中发挥关键作用。干细胞生物学领域受到了广泛关注，它在修复多种疾病表型的受损组织方面显示出了巨大的潜力。
在本综述中，我们对文献进行了全面回顾，评估了伤口治疗的现状，同时讨论了基于干细胞产品背后的原理和吸引力。我们还提出了随着新的基于干细胞的疗法不断发展以及该技术向临床转化而仍然存在的两个挑战。
鉴于这项较新技术在伤口愈合领域尚处于相对早期阶段，围绕其有效应用仍存在诸多挑战，包括确定理想的干细胞使用群体以及确定最佳的细胞递送方法。然而，已经取得了显著的进展，多项临床试验开始证明有可靠的临床益处。
干细胞技术的上升趋势提供了一个令人兴奋的机会，通过可控地应用基于细胞的再生疗法对患者预后产生积极影响。
