Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Laboratory of Controllable Nanopharmaceuticals, Chinese Academy of Sciences (CAS) Center for Excellence in Nanoscience; and CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology , First North Road, Zhongguancun, Beijing 100190, P. R. China.
ACS Nano. 2016 Sep 27;10(9):8732-7. doi: 10.1021/acsnano.6b04207. Epub 2016 Sep 16.
Zwitterionic nanoparticles are generally considered nontoxic and noninteracting. Here, we report effective and selective antimicrobial activity of zwitterionic gold nanoparticles (AuNP) through modulation NP size and surface charge orientation. Using a set of 2, 4, and 6 nm core AuNPs, increasing particle size increased antimicrobial efficiency through bacterial membrane disruption. Further improvement was observed through control of the ligand structure, generating antimicrobial particles with low hemolytic activity and demonstrating the importance of size and surface structure in dictating the bioactivity properties of nanomaterials.
两性离子纳米粒子通常被认为是无毒且无相互作用的。在这里，我们通过调节 NP 尺寸和表面电荷方向，报道了两性离子金纳米粒子（AuNP）的有效和选择性抗菌活性。使用一组 2、4 和 6nm 核 AuNP，通过破坏细菌细胞膜，增加颗粒尺寸提高了抗菌效率。通过控制配体结构进一步改善，生成具有低溶血活性的抗菌粒子，并证明了尺寸和表面结构在决定纳米材料生物活性性质方面的重要性。
