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用于生物传感应用的分子识别与特异性相互作用

Molecular Recognition and Specific Interactions for Biosensing Applications.

作者信息

Kim Dong Chung, Kang Dae Joon

机构信息

BK 21 Physics Research Division, Institute of Basic Science, SKKU Advanced Institute of Nanotechnology, Center for Nanotubes and Nanostructured Composites, Sungkyunkwan University, Suwon 440-746, Korea.

出版信息

Sensors (Basel). 2008 Oct 23;8(10):6605-6641. doi: 10.3390/s8106605.

DOI:10.3390/s8106605
PMID:27873889
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3707470/
Abstract

Molecular recognition and specific interactions are reliable and versatile routes for site-specific and well-oriented immobilization of functional biomolecules on surfaces. The control of surface properties via the molecular recognition and specific interactions at the nanoscale is a key element for the nanofabrication of biosensors with high sensitivity and specificity. This review intends to provide a comprehensive understanding of the molecular recognition- and specific interaction-mediated biosensor fabrication routes that leads to biosensors with well-ordered and controlled structures on both nanopatterned surfaces and nanomaterials. Herein self-assembly of the biomolecules via the molecular recognition and specific interactions on nanoscaled surfaces as well as nanofabrication techniques of the biomolecules for biosensor architecture are discussed. We also describe the detection of molecular recognition- and specific interaction-mediated molecular binding as well as advantages of nanoscale detection.

摘要

分子识别和特异性相互作用是将功能性生物分子在表面进行位点特异性且取向良好固定的可靠且通用的途径。通过纳米尺度的分子识别和特异性相互作用来控制表面性质，是制造具有高灵敏度和特异性的生物传感器的关键要素。本综述旨在全面了解分子识别和特异性相互作用介导的生物传感器制造途径，这些途径能够在纳米图案化表面和纳米材料上构建具有有序且可控结构的生物传感器。本文讨论了生物分子通过在纳米尺度表面上的分子识别和特异性相互作用进行的自组装，以及用于生物传感器架构的生物分子的纳米制造技术。我们还描述了分子识别和特异性相互作用介导的分子结合的检测以及纳米尺度检测的优势。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/ed5b28345d48/sensors-08-06605f15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/f6fd4a8a5fc2/sensors-08-06605f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/4f7178de6739/sensors-08-06605f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/bc2b43938743/sensors-08-06605f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/5f6e611f877b/sensors-08-06605f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/fb738d0c2295/sensors-08-06605f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/d4efc961dff0/sensors-08-06605f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/57613bb464de/sensors-08-06605f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/7d086a8640a4/sensors-08-06605f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/b8b295f43c06/sensors-08-06605f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/f3b076f2f2ac/sensors-08-06605f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/b02ae05bea79/sensors-08-06605f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/953b3a5da93e/sensors-08-06605f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/ed76c2d16ea3/sensors-08-06605f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/a2edf40d7b4b/sensors-08-06605f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/ed5b28345d48/sensors-08-06605f15.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/f6fd4a8a5fc2/sensors-08-06605f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/4f7178de6739/sensors-08-06605f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/bc2b43938743/sensors-08-06605f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/5f6e611f877b/sensors-08-06605f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/fb738d0c2295/sensors-08-06605f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/d4efc961dff0/sensors-08-06605f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/57613bb464de/sensors-08-06605f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/7d086a8640a4/sensors-08-06605f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/b8b295f43c06/sensors-08-06605f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/f3b076f2f2ac/sensors-08-06605f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/b02ae05bea79/sensors-08-06605f11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/953b3a5da93e/sensors-08-06605f12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/ed76c2d16ea3/sensors-08-06605f13.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/a2edf40d7b4b/sensors-08-06605f14.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4262/3707470/ed5b28345d48/sensors-08-06605f15.jpg

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