基于临床需求的医用金属材料研发。
Research and development of metals for medical devices based on clinical needs.
作者信息
Hanawa Takao
机构信息
Department of Metallic Biomaterials, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-surugadai, Chiyoda-ku, Tokyo, 101-0062, Japan.
出版信息
Sci Technol Adv Mater. 2012 Dec 13;13(6):064102. doi: 10.1088/1468-6996/13/6/064102. eCollection 2012 Dec.
Abstract
The current research and development of metallic materials used for medicine and dentistry is reviewed. First, the general properties required of metals used in medical devices are summarized, followed by the needs for the development of + type Ti alloys with large elongation and type Ti alloys with a low Young's modulus. In addition, nickel-free Ni-Ti alloys and austenitic stainless steels are described. As new topics, we review metals that are bioabsorbable and compatible with magnetic resonance imaging. Surface treatment and modification techniques to improve biofunctions and biocompatibility are categorized, and the related problems are presented at the end of this review. The metal surface may be biofunctionalized by various techniques, such as dry and wet processes. These techniques make it possible to apply metals to scaffolds in tissue engineering.
摘要
本文综述了用于医学和牙科的金属材料的当前研发情况。首先，总结了医疗设备中使用的金属所需的一般性能，接着介绍了开发具有大伸长率的 + 型钛合金和低杨氏模量的 型钛合金的需求。此外，还描述了无镍镍钛合金和奥氏体不锈钢。作为新的主题，我们回顾了可生物吸收且与磁共振成像兼容的金属。对改善生物功能和生物相容性的表面处理和改性技术进行了分类，并在本综述末尾提出了相关问题。金属表面可通过各种技术进行生物功能化，如干法和湿法工艺。这些技术使金属能够应用于组织工程支架。
相似文献
1
Research and development of metals for medical devices based on clinical needs.基于临床需求的医用金属材料研发。
Sci Technol Adv Mater. 2012 Dec 13;13(6):064102. doi: 10.1088/1468-6996/13/6/064102. eCollection 2012 Dec.
2
A review on nickel-free nitrogen containing austenitic stainless steels for biomedical applications.无镍含氮奥氏体不锈钢在生物医学应用中的研究综述。
Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):3563-75. doi: 10.1016/j.msec.2013.06.002. Epub 2013 Jun 12.
3
Deformation-induced changeable Young's modulus with high strength in β-type Ti-Cr-O alloys for spinal fixture.β 型 Ti-Cr-O 合金用于脊柱固定器的高弹性模量变形诱导可变性和高强度。
J Mech Behav Biomed Mater. 2014 Feb;30:205-13. doi: 10.1016/j.jmbbm.2013.11.001. Epub 2013 Nov 15.
4
Biomedical titanium alloys with Young's moduli close to that of cortical bone.具有接近皮质骨杨氏模量的生物医用钛合金。
Regen Biomater. 2016 Sep;3(3):173-85. doi: 10.1093/rb/rbw016. Epub 2016 Mar 8.
5
Beta type Ti-Mo alloys with changeable Young's modulus for spinal fixation applications.用于脊柱固定应用的可改变杨氏模量的β型 Ti-Mo 合金。
Acta Biomater. 2012 May;8(5):1990-7. doi: 10.1016/j.actbio.2012.02.004. Epub 2012 Feb 9.
6
Histomorphometric assessments of peri-implant bone around Ti-Nb-Sn alloy implants with low Young's modulus.Ti-Nb-Sn 低弹性模量合金种植体周围骨的组织形态计量学评估。
Dent Mater J. 2020 Jan 31;39(1):148-153. doi: 10.4012/dmj.2018-376. Epub 2019 Oct 30.
7
Thermal and mechanical characteristics of stainless steel, titanium-molybdenum, and nickel-titanium archwires.不锈钢、钛钼合金和镍钛弓丝的热学和力学特性。
Am J Orthod Dentofacial Orthop. 2007 Feb;131(2):229-37. doi: 10.1016/j.ajodo.2005.05.054.
8
Effect of Zr Content on Phase Stability, Deformation Behavior, and Young's Modulus in Ti-Nb-Zr Alloys.Zr含量对Ti-Nb-Zr合金的相稳定性、变形行为及杨氏模量的影响
Materials (Basel). 2020 Jan 19;13(2):476. doi: 10.3390/ma13020476.
9
Optimization of Cr content of metastable β-type Ti-Cr alloys with changeable Young's modulus for spinal fixation applications.用于脊柱固定应用的可改变杨氏模量的亚稳β型 Ti-Cr 合金的 Cr 含量优化。
Acta Biomater. 2012 Jul;8(6):2392-400. doi: 10.1016/j.actbio.2012.02.010. Epub 2012 Feb 15.
10
Nanocrystalline β-Ti alloy with high hardness, low Young's modulus and excellent in vitro biocompatibility for biomedical applications.用于生物医学应用的具有高硬度、低杨氏模量和优异体外生物相容性的纳米晶 β-Ti 合金。
Mater Sci Eng C Mater Biol Appl. 2013 Aug 1;33(6):3530-6. doi: 10.1016/j.msec.2013.04.044. Epub 2013 Apr 29.
引用本文的文献
1
Enhancing Implantable Medical Devices: Surface Functionalization of Titanium with Quaternary Ammonium Salts for Antibacterial Adhesion Properties.增强植入式医疗设备：用季铵盐对钛进行表面功能化以实现抗菌粘附特性
ACS Omega. 2025 Feb 5;10(6):5582-5592. doi: 10.1021/acsomega.4c08503. eCollection 2025 Feb 18.
2
Design and Biofunctionalization of Cloud Sponge-Inspired Scaffolds for Enhanced Bone Cell Performance.受云海绵启发的支架的设计与生物功能化以增强骨细胞性能
ACS Appl Bio Mater. 2024 Dec 16;7(12):8281-8293. doi: 10.1021/acsabm.4c01065. Epub 2024 Nov 16.
3
Transformation behaviour of salts composed of calcium ions and phosphate esters with different linear alkyl chain structures in a simulated body fluid modified with alkaline phosphatase.在经碱性磷酸酶修饰的模拟体液中，具有不同直链烷基链结构的钙离子与磷酸酯所组成盐的转变行为
Sci Technol Adv Mater. 2022 May 30;23(1):341-351. doi: 10.1080/14686996.2022.2074801. eCollection 2022.
4
Recent Advancements in Materials and Coatings for Biomedical Implants.生物医学植入物材料与涂层的最新进展
Gels. 2022 May 21;8(5):323. doi: 10.3390/gels8050323.
5
ZnO-based antimicrobial coatings for biomedical applications.基于氧化锌的抗菌生物医学涂层。
Bioprocess Biosyst Eng. 2022 Sep;45(9):1421-1445. doi: 10.1007/s00449-022-02733-9. Epub 2022 May 24.
6
Titanium Surface Modification for Implantable Medical Devices with Anti-Bacterial Adhesion Properties.具有抗菌粘附特性的可植入医疗设备的钛表面改性
Materials (Basel). 2022 May 3;15(9):3283. doi: 10.3390/ma15093283.
7
Toxicological assessment of nanocrystalline metal alloys with potential applications in the aeronautical field.纳米晶金属合金的毒理学评估及其在航空领域的潜在应用。
Sci Rep. 2022 Jan 27;12(1):1523. doi: 10.1038/s41598-022-05406-5.
8
A state-of-the-art review of the fabrication and characteristics of titanium and its alloys for biomedical applications.用于生物医学应用的钛及其合金的制造与特性的最新综述。
Biodes Manuf. 2022;5(2):371-395. doi: 10.1007/s42242-021-00170-3. Epub 2021 Oct 26.
9
Biocompatibility and patency of a novel titanium vascular anastomotic device in a pig jugular vein.新型钛血管吻合器在猪颈静脉中的生物相容性和通畅性。
Sci Rep. 2021 Sep 1;11(1):17512. doi: 10.1038/s41598-021-97157-y.
10
Influences of Stent Design on In-Stent Restenosis and Major Cardiac Outcomes: A Scoping Review and Meta-Analysis.支架设计对支架内再狭窄和主要心脏结局的影响：一项范围综述和荟萃分析。
Cardiovasc Eng Technol. 2022 Feb;13(1):147-169. doi: 10.1007/s13239-021-00569-0. Epub 2021 Aug 18.
本文引用的文献
1
Microstructure and mechanical properties of as-cast Zr-Nb alloys.铸态 Zr-Nb 合金的微观结构和力学性能。
Acta Biomater. 2011 Dec;7(12):4278-84. doi: 10.1016/j.actbio.2011.07.020. Epub 2011 Jul 30.
2
Bone healing of commercial oral implants with RGD immobilization through electrodeposited poly(ethylene glycol) in rabbit cancellous bone.商用口腔种植体经电沉积聚乙二醇固定 RGD 后在兔松质骨中的骨愈合。
Acta Biomater. 2011 Aug;7(8):3222-9. doi: 10.1016/j.actbio.2011.04.015. Epub 2011 Apr 22.
3
Effects of electrodeposited poly(ethylene glycol) on biofilm adherence to titanium.电沉积聚乙二醇对钛生物膜黏附的影响。
J Biomed Mater Res A. 2010 Dec 15;95(4):1105-13. doi: 10.1002/jbm.a.32932. Epub 2010 Sep 28.
4
Microstructure and magnetic susceptibility of as-cast Zr-Mo alloys.铸态 Zr-Mo 合金的微观结构和磁化率。
Acta Biomater. 2010 Mar;6(3):1033-8. doi: 10.1016/j.actbio.2009.09.013. Epub 2009 Sep 20.
5
Coating process and early stage adhesion evaluation of poly(2-hydroxy-ethyl-methacrylate) hydrogel coating of 316L steel surface for stent applications.用于支架应用的316L钢表面聚（甲基丙烯酸2-羟乙酯）水凝胶涂层的涂覆工艺及早期附着力评估
J Mater Sci Mater Med. 2009 Jul;20(7):1541-51. doi: 10.1007/s10856-009-3699-z. Epub 2009 Mar 9.
6
Characterization of the spatial immobilization manner of poly(ethylene glycol) to a titanium surface with immersion and electrodeposition and its effects on platelet adhesion.聚乙二醇在钛表面的浸涂和电沉积固定方式及其对血小板黏附的影响的研究。
J Biomed Mater Res A. 2010 Jan;92(1):350-8. doi: 10.1002/jbm.a.32375.
7
An overview of biofunctionalization of metals in Japan.日本金属生物功能化概述。
J R Soc Interface. 2009 Jun 6;6 Suppl 3(Suppl 3):S361-9. doi: 10.1098/rsif.2008.0427.focus. Epub 2009 Jan 20.
8
Calcification by MC3T3-E1 cells on RGD peptide immobilized on titanium through electrodeposited PEG.通过电沉积聚乙二醇固定在钛上的RGD肽上MC3T3-E1细胞的钙化
Biomaterials. 2009 Mar;30(7):1281-6. doi: 10.1016/j.biomaterials.2008.11.030. Epub 2008 Dec 16.
9
Effect of pH on the interaction between zwitterions and titanium oxide.pH对两性离子与二氧化钛之间相互作用的影响。
J Colloid Interface Sci. 2009 Feb 1;330(1):138-43. doi: 10.1016/j.jcis.2008.10.042. Epub 2008 Nov 12.
10
Gene expression monitoring in osteoblasts on titanium coated with fibronectin-derived peptide.在涂有纤连蛋白衍生肽的钛表面上的成骨细胞中的基因表达监测
Dent Mater J. 2008 Sep;27(5):744-50. doi: 10.4012/dmj.27.744.
Zotero 插件