Taherkhani Shima, Suzuki Katsuhiko, Ruhee Ruheea Taskin
Department of Exercise Physiology, Faculty of Sport Sciences, University of Guilan, Rasht 4199843653, Iran.
Faculty of Sport Sciences, Waseda University, 2-579-15 Mikajima, Tokorozawa 359-1192, Japan.
Antioxidants (Basel). 2021 Apr 13;10(4):594. doi: 10.3390/antiox10040594.
One of the leading causes of obesity associated with oxidative stress (OS) is excessive consumption of nutrients, especially fast-foods, and a sedentary lifestyle, characterized by the ample accumulation of lipid in adipose tissue (AT). When the body needs energy, the lipid is broken down into glycerol (G) and free fatty acids (FFA) during the lipolysis process and transferred to various tissues in the body. Materials secreted from AT, especially adipocytokines (interleukin (IL)-1β, IL-6, and tumor necrosis factor-α (TNF-α)) and reactive oxygen species (ROS), are impressive in causing inflammation and OS of AT. There are several ways to improve obesity, but researchers have highly regarded the use of antioxidant supplements due to their neutralizing properties in removing ROS. In this review, we have examined the AT response to OS to antioxidant supplements focusing on animal studies. The results are inconsistent due to differences in the study duration and diversity in animals (strain, age, and sex). Therefore, there is a need for different studies, especially in humans.
与氧化应激（OS）相关的肥胖主要原因之一是营养物质的过度摄入，尤其是快餐，以及久坐不动的生活方式，其特征是脂肪组织（AT）中脂质大量堆积。当身体需要能量时，脂质在脂肪分解过程中分解为甘油（G）和游离脂肪酸（FFA），并转移到身体的各个组织。AT分泌的物质，特别是脂肪细胞因子（白细胞介素（IL）-1β、IL-6和肿瘤坏死因子-α（TNF-α））和活性氧（ROS），在引发AT的炎症和OS方面作用显著。改善肥胖有多种方法，但由于抗氧化剂补充剂在清除ROS方面的中和特性，研究人员对其高度重视。在本综述中，我们重点关注动物研究，考察了AT对抗氧化剂补充剂的OS反应。由于研究持续时间的差异和动物（品系、年龄和性别）的多样性，结果并不一致。因此，需要进行不同的研究，尤其是在人类中进行研究。
