Andrés Germán
Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas and Universidad Autónoma de Madrid, Madrid, Spain
J Virol. 2017 Jan 31;91(4). doi: 10.1128/JVI.01906-16. Print 2017 Feb 15.
African swine fever virus (ASFV) is a large, multienveloped DNA virus composed of a genome-containing core successively wrapped by an inner lipid envelope, an icosahedral protein capsid, and an outer lipid envelope. In keeping with this structural complexity, recent studies have revealed an intricate entry program. This Gem highlights how ASFV uses two alternative pathways, macropinocytosis and clathrin-mediated endocytosis, to enter into the host macrophage and how the endocytosed particles undergo a stepwise, low pH-driven disassembly leading to inner envelope fusion and core delivery in the cytoplasm.
非洲猪瘟病毒（ASFV）是一种大型的、多包膜DNA病毒，其基因组核心依次被内脂质包膜、二十面体蛋白衣壳和外脂质包膜包裹。鉴于这种结构复杂性，最近的研究揭示了一个复杂的进入程序。这篇综述强调了ASFV如何利用巨胞饮作用和网格蛋白介导的内吞作用这两种替代途径进入宿主巨噬细胞，以及内吞的病毒颗粒如何经历逐步的、低pH值驱动的解体，导致内膜融合并将病毒核心递送至细胞质中。
