Bogner Catherine W, Kamdem Ramsay S T, Sichtermann Gisela, Matthäus Christian, Hölscher Dirk, Popp Jürgen, Proksch Peter, Grundler Florian M W, Schouten Alexander
Institute of Crop Science and Resource Conservation (INRES), Department of Molecular Phytomedicine, University of Bonn, Karlrobert-Kreiten Str. 13, 53115, Bonn, Germany.
Institute of Pharmaceutical Biology and Biotechnology, Heinrich-Heine-University Düsseldorf, Universitäts Str. 1. Building. 26.23, 40225, Düsseldorf, Germany.
Microb Biotechnol. 2017 Jan;10(1):175-188. doi: 10.1111/1751-7915.12467. Epub 2016 Dec 19.
In order to replace particularly biohazardous nematocides, there is a strong drive to finding natural product-based alternatives with the aim of containing nematode pests in agriculture. The metabolites produced by the fungal endophyte Fusarium oxysporum 162 when cultivated on rice media were isolated and their structures elucidated. Eleven compounds were obtained, of which six were isolated from a Fusarium spp. for the first time. The three most potent nematode-antagonistic compounds, 4-hydroxybenzoic acid, indole-3-acetic acid (IAA) and gibepyrone D had LC values of 104, 117 and 134 μg ml , respectively, after 72 h. IAA is a well-known phytohormone that plays a role in triggering plant resistance, thus suggesting a dual activity, either directly, by killing or compromising nematodes, or indirectly, by inducing defence mechanisms against pathogens (nematodes) in plants. Such compounds may serve as important leads in the development of novel, environmental friendly, nematocides.
为了替代具有特别生物危害性的杀线虫剂，人们强烈希望找到基于天然产物的替代品，以便在农业中控制线虫害虫。对真菌内生尖孢镰刀菌162在水稻培养基上培养时产生的代谢产物进行了分离，并阐明了其结构。获得了11种化合物，其中6种是首次从镰刀菌属中分离出来的。三种最有效的对线虫具有拮抗作用的化合物，即4-羟基苯甲酸、吲哚-3-乙酸（IAA）和吉贝吡喃酮D，在72小时后的LC值分别为104、117和134μg/ml。IAA是一种著名的植物激素，在触发植物抗性方面发挥作用，因此表明其具有双重活性，要么直接通过杀死或损害线虫，要么间接通过诱导植物针对病原体（线虫）的防御机制。这类化合物可能成为开发新型、环境友好型杀线虫剂的重要先导物。
