Kafrouni Lina, Savadogo Oumarou
Department of Chemical Engineering, Polytechnique Montréal, C.P. 6079, Succursale Centre-ville, Montreal, QC, H3C 3A7, Canada.
Laboratory of New Materials for Energy and Electrochemistry Systems (LaNoMat), Montreal, Canada.
Prog Biomater. 2016 Dec;5(3-4):147-160. doi: 10.1007/s40204-016-0054-6. Epub 2016 Sep 6.
Recent advances in nanomaterials science contributed to develop new micro- and nano-devices as potential diagnostic and therapeutic tools in the field of oncology. The synthesis of superparamagnetic nanoparticles (SPMNPs) has been intensively studied, and the use of these particles in magnetic hyperthermia therapy has demonstrated successes in treatment of cancer. However, some physical limitations have been found to impact the heating efficiency required to kill cancer cells. Moreover, the bio-safety of NPs remains largely unexplored. The primary goals of this review are to summarize the recent progress in the development of magnetic nanoparticles (MNPs) for hyperthermia, and discuss the limitations and advances in the synthesis of these particles. Based on this knowledge, new perspectives on development of new biocompatible and biofunctional nanomaterials for magnetic hyperthermia are discussed.
纳米材料科学的最新进展推动了新型微纳器件的开发,这些器件有望成为肿瘤学领域的诊断和治疗工具。超顺磁性纳米粒子(SPMNPs)的合成已得到深入研究,并且这些粒子在磁热疗中的应用已在癌症治疗中取得了成功。然而,已发现一些物理限制会影响杀死癌细胞所需的加热效率。此外,纳米粒子的生物安全性在很大程度上仍未得到探索。本综述的主要目标是总结用于热疗的磁性纳米粒子(MNPs)开发的最新进展,并讨论这些粒子合成中的局限性和进展。基于这些知识,探讨了用于磁热疗的新型生物相容性和生物功能纳米材料开发的新观点。