DiGiacomo R F, Deeb B J, Giddens W E, Bernard B L, Chengappa M M
Department of Comparative Medicine, School of Medicine, University of Washington, Seattle 98195.
Am J Vet Res. 1989 Sep;50(9):1460-5.
Atrophic rhinitis was detected in New Zealand White rabbits when upper respiratory tract disease was evaluated during a vaccine field trial for the prevention of pasteurellosis. Of 52 adult rabbits euthanatized and necropsied, 26 (50%) had evidence of turbinate atrophy. Atrophy was detected in 77% of rabbits with Pasteurella multocida infection only, 71% of rabbits with concurrent P multocida and Bordetella bronchiseptica infections, and 6% of rabbits with B bronchiseptica infection only. Grossly, turbinate atrophy was characterized by a mild to severe loss or diminution in the maxilloturbinates. Histologically, turbinate bones were small and irregular in thickness and had numerous osteoclasts and osteoblasts. A neutrophilic exudate filled the nasal passages, and infiltrates of neutrophils and lymphocytes were detected in the mucosa and submucosa of the nasal turbinates. Rhinitis was significantly (P less than 0.001) associated with turbinate atrophy. Isolates of P multocida from rabbits with turbinate atrophy were serotype A:12.
在一项预防巴氏杆菌病的疫苗现场试验中评估家兔上呼吸道疾病时，在新西兰白兔中检测到萎缩性鼻炎。在52只实施安乐死并进行尸检的成年兔中，26只（50%）有鼻甲萎缩的证据。仅感染多杀性巴氏杆菌的兔中77%检测到萎缩，同时感染多杀性巴氏杆菌和支气管败血波氏杆菌的兔中71%检测到萎缩，仅感染支气管败血波氏杆菌的兔中6%检测到萎缩。大体上，鼻甲萎缩的特征是上颌鼻甲出现轻度至重度的缺失或缩小。组织学上，鼻甲骨质小且厚度不规则，有大量破骨细胞和成骨细胞。中性粒细胞渗出物充满鼻腔通道，在鼻甲黏膜和黏膜下层检测到中性粒细胞和淋巴细胞浸润。鼻炎与鼻甲萎缩显著相关（P<0.001）。来自有鼻甲萎缩的兔的多杀性巴氏杆菌分离株为A:12血清型。
