氟喹诺酮类抗菌剂环丙沙星和依诺沙星与脂质体的相互作用。
Interaction of the fluoroquinolone antimicrobial agents ciprofloxacin and enoxacin with liposomes.
作者信息
Bedard J, Bryan L E
机构信息
Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada.
出版信息
Antimicrob Agents Chemother. 1989 Aug;33(8):1379-82. doi: 10.1128/AAC.33.8.1379.
Abstract
The interaction between ciprofloxacin and enoxacin and phospholipid-containing bilayers was examined as the initial step in transmembrane diffusion processes. By using cosedimentation, maximal association of liposomes and 14C-labeled enoxacin and ciprofloxacin was detected at acidic and neutral pHs. Aqueous solubility of ciprofloxacin, enoxacin, and norfloxacin was poorest at neutral pH and greater at alkaline or acidic pHs. These investigations suggest that the interaction occurs because of ionic and hydrophobic forces and is nonsaturable up to 20 micrograms/ml.
摘要
作为跨膜扩散过程的第一步，研究了环丙沙星与依诺沙星和含磷脂双层之间的相互作用。通过共沉降法，在酸性和中性pH条件下检测到脂质体与14C标记的依诺沙星和环丙沙星的最大缔合。环丙沙星、依诺沙星和诺氟沙星在中性pH条件下的水溶性最差，在碱性或酸性pH条件下则更高。这些研究表明，这种相互作用是由于离子力和疏水作用力而发生的，并且在高达20微克/毫升的浓度下不饱和。
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