Dutra Heverton Leandro Carneiro, Caragata Eric Pearce, Moreira Luciano Andrade
Mosquitos Vetores: Endossimbiontes e Interação Patógeno-Vetor, Centro de Pesquisas René Rachou - Fiocruz, Belo Horizonte, MG, Brazil.
Bioessays. 2017 Feb;39(2). doi: 10.1002/bies.201600175. Epub 2016 Dec 27.
Mayaro, Oropouche, and O'Nyong-Nyong share many traits with more prominent arboviruses, like dengue and yellow fever, chikungunya, and Zika. These include severe clinical symptoms, multiple animal hosts, and widespread vector species living in close proximity to human habitats, all of which constitute significant risk factors for more frequent outbreaks in the future, greatly increasing the potential of these hidden enemies to follow Zika and become the next wave of global arboviral threats. Critically, the current dearth of knowledge on these arboviruses might impede the success of future control efforts, including the potential application of Wolbachia pipientis. This bacterium inherently possesses broad anti-pathogen properties and a means of genetic drive that allows it to eliminate or replace target vector populations. We conclude that control of obscure arboviruses with Wolbachia might be possible, but successful implementation will be critically dependent on the ability to transinfect key vector species.
马亚罗病毒、奥罗普切病毒和奥尼永尼永病毒与登革热、黄热病、基孔肯雅热和寨卡病毒等更著名的虫媒病毒有许多共同特征。这些特征包括严重的临床症状、多种动物宿主以及生活在人类栖息地附近的广泛传播的病媒物种，所有这些都构成了未来更频繁爆发的重大风险因素，极大地增加了这些隐藏敌人跟随寨卡病毒并成为下一波全球虫媒病毒威胁的可能性。至关重要的是，目前对这些虫媒病毒的了解匮乏可能会阻碍未来防控工作的成功，包括潜在应用沃尔巴克氏体。这种细菌本身具有广泛的抗病原体特性和一种基因驱动手段，使其能够消除或取代目标病媒种群。我们得出结论，利用沃尔巴克氏体控制隐匿性虫媒病毒或许可行，但成功实施将严重依赖于对关键病媒物种进行转染的能力。
