无金属硼掺杂石墨烯量子点的顺磁性质及其在安全磁共振成像中的应用。
Paramagnetic Properties of Metal-Free Boron-Doped Graphene Quantum Dots and Their Application for Safe Magnetic Resonance Imaging.
机构信息
Department of Materials Science and Engineering, University of Washington, Seattle, WA, 98195, USA.
Center for Nanophase Materials Sciences and Chemical Science Division, Oak Ridge National Laboratory, Oak Ridge, TN, 37831, USA.
出版信息
Adv Mater. 2017 Mar;29(11). doi: 10.1002/adma.201605416. Epub 2016 Dec 27.
Abstract
A boron-doped graphene quantum dot (B-GQD) as a metal-free multimodal contrast agent (CA) for safe magnetic resonance imaging and fluorescence imaging is reported. In vivo T -weighted magnetic resonance images show that B-GQDs induce significant contrast enhancement on the heart, liver, spleen, and kidney, and sustain for more than 1 h, about 10 times longer than Gd-based CAs currently used in clinic.
摘要
报道了一种硼掺杂石墨烯量子点（B-GQD）作为无金属的多模态对比剂（CA），用于安全的磁共振成像和荧光成像。体内 T 加权磁共振图像显示，B-GQDs 在心、肝、脾、肾等部位引起显著的对比增强，持续时间超过 1 小时，比目前临床使用的基于 Gd 的 CA 长约 10 倍。
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