Saarland University, Institute of Experimental Ophthalmology, Kirrberger Street 100, Building 22, 66421 Homburg/Saar, Germany.
Saarland University Medical Center (UKS), Department of Ophthalmology, Kirrberger Street 100, Building 22, 66421 Homburg/Saar, Germany.
J Biomed Opt. 2017 Jan 1;22(1):16001. doi: 10.1117/1.JBO.22.1.016001.
Vision loss due to corneal injuries or diseases can be treated by transplantation of human corneal grafts (keratoplasty). However, quality assurance in retrieving and cultivating the tissue transplants is confined to visual and microbiological testing. To identify previous refractive surgery or morphological alterations, an automatic, noncontact, sterile screening procedure is required. Twenty-three corneal grafts have been measured in organ culture with a clinical spectral-domain optical coherence tomographer. Employing a biconic surface fit with 10 degrees of freedom, the radii of curvature and conic constants could be estimated for the anterior and posterior corneal surfaces. Thereupon, central corneal thickness, refractive values, and astigmatism have been calculated. Clinical investigations are required to elaborate specific donor–host matching in the future.
由于角膜损伤或疾病导致的视力丧失可以通过移植人类角膜移植物（角膜移植术）来治疗。然而，在获取和培养组织移植物时，质量保证仅限于视觉和微生物学测试。为了识别以前的屈光手术或形态改变，需要一种自动、非接触、无菌的筛选程序。使用临床光谱域光相干断层扫描仪对 23 个在器官培养中的角膜移植物进行了测量。采用具有 10 个自由度的双锥形表面拟合，可估算前、后角膜表面的曲率半径和圆锥常数。随后，计算了中央角膜厚度、屈光值和散光。未来需要进行临床研究来详细说明特定的供体-宿主匹配。
