Dinali Ranmadugala, Ebrahiminezhad Alireza, Manley-Harris Merilyn, Ghasemi Younes, Berenjian Aydin
a Faculty of Science and Engineering , University of Waikato , Hamilton , New Zealand.
b Noncommunicable Diseases Research Center, Fasa University of Medical Sciences , Fasa , Iran.
Crit Rev Microbiol. 2017 Aug;43(4):493-507. doi: 10.1080/1040841X.2016.1267708. Epub 2017 Jan 10.
Iron oxide nanoparticles (IONs) are one of the most developed and used nanomaterials in biotechnology and microbiology. These particles have unique physicochemical properties, which make them unique among nanomaterials. Therefore, many experiments have been conducted to develop facile synthesis methods for these particles and to make them biocompatible. Various effects of IONs on microorganisms have been reported. Depending on the microbial strain and nanoparticle (NP) concentration, IONs can stimulate or inhibit microbial growth. Due to the superparamagnetic properties of IONs, these NPs have used as nano sources of heat for hyperthermia in infected tissues. Antibiotic-loaded IONs are used for targeted delivery of chemical therapy direct to the infected organ and IONs have been used as a dirigible carrier for more potent antimicrobial nanomaterials such as silver nanoparticles. Magnetic NPs have been used for specific separation of pathogen and non-pathogen bacterial strains. Very recently, IONs were used as a novel tool for magnetic immobilization of microbial cells and process intensification in a biotechnological process. This review provides an overview of application of IONs in different microbial processes. Recommendations are also given for areas of future research.
氧化铁纳米颗粒（IONs）是生物技术和微生物学领域中研发最为成熟且应用最为广泛的纳米材料之一。这些颗粒具有独特的物理化学性质，这使其在纳米材料中独树一帜。因此，人们开展了诸多实验来开发这些颗粒的简便合成方法，并使其具有生物相容性。已有报道指出IONs对微生物具有多种作用。根据微生物菌株和纳米颗粒（NP）浓度的不同，IONs可以刺激或抑制微生物生长。由于IONs具有超顺磁性，这些纳米颗粒已被用作感染组织热疗的纳米热源。负载抗生素的IONs用于将化学疗法直接靶向递送至感染器官，并且IONs已被用作更有效的抗菌纳米材料（如银纳米颗粒）的可控载体。磁性纳米颗粒已用于病原体和非病原体细菌菌株的特异性分离。最近，IONs被用作微生物细胞磁性固定和生物技术过程强化的新型工具。本综述概述了IONs在不同微生物过程中的应用。同时也对未来的研究领域提出了建议。
