Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.
Cold Spring Harb Perspect Biol. 2017 Nov 1;9(11):a029470. doi: 10.1101/cshperspect.a029470.
The ability of structure-based design to control the shape and reactivity-the atomic-level chemistry-of an immunogen argues for it being one of the "most powerful" immunogen-design strategies. But antigenic reactivity is only one of the properties required to induce a protective immune response. Here, a multidimensional approach is used to exemplify the enabling role atomic-level information can play in the development of immunogens against three viral pathogens, respiratory syncytial virus, influenza A virus, and human immunodeficiency virus (HIV), which have resisted standard approaches to vaccine development. Overall, structure-based strategies incorporating B-cell ontogenies and viral evasion mechanisms appear exceptionally powerful.
基于结构的设计能够控制免疫原的形状和反应性——即原子水平的化学性质——这使得它成为“最强大”的免疫原设计策略之一。但是，抗原反应性只是诱导保护性免疫应答所必需的特性之一。在这里，采用多维方法来说明原子水平信息在开发针对三种病毒病原体（呼吸道合胞病毒、甲型流感病毒和人类免疫缺陷病毒（HIV））的免疫原方面可以发挥的作用，这些病原体对疫苗开发的标准方法有抵抗力。总的来说，包含 B 细胞发生和病毒逃逸机制的基于结构的策略似乎格外强大。
