Zaprutko Tomasz, Kopciuch Dorota, Kus Krzysztof, Merks Piotr, Nowicka Monika, Augustyniak Izabela, Nowakowska Elżbieta
Department of Pharmacoeconomics and Social Pharmacy, Poznan University of Medical Sciences, Poznań, Poland.
Department of Pharmaceutical Technology, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, Toruń, Poland.
PLoS One. 2017 Feb 27;12(2):e0172753. doi: 10.1371/journal.pone.0172753. eCollection 2017.
Medications and their prices are key issues for healthcare. Although access to medicines at affordable prices had been specified as a key objective of the European Health Policy, it seems that these goals have not been achieved. Therefore, we attempted an evaluation of affordability of selected medicines at full prices.
The analysis concerned 2012 and was conducted between 2013 and 2015 in all the European Union (EU) countries divided into 3 groups depending on the date of their accession to the EU. Finally, we considered 9 originators used in the treatment of schizophrenia and multiple sclerosis. Information on drug prices were collected from pharmacies. Participation in the study was voluntary and anonymous in order to avoid accusations of advertising. To evaluate affordability, several factors were used (e.g. minimum earnings and Gini coefficient). Due to unavailability in some countries, the exact number of analyzed medicines varies.
Drug prices vary significantly between EU Member States. Almost eleven fold difference was observed between Germany (EUR 1451.17) and Croatia (EUR 132.77) in relation to Interferone beta-1a 22 μg. Generally, prices were the highest in Germany. The cheapest drugs were found in various countries but never in the poorest ones like Bulgaria or Romania. Discrepancies in wages were observed too (the smallest minimum wage was EUR 138.00 in Bulgaria and the highest EUR 1801.00 in Luxembourg). Full price of olanzapine 5mg, however, was higher in Bulgaria (EUR 64.53) than, for instance, in Belgium (EUR 37.26).
Analyzed medications are still unaffordable for many citizens of the EU. Besides, access to medicines is also impaired e.g. due to parallel trade. Unaffordability of medications may lead to the patients' non-compliance and therefore to increased direct and indirect costs of treatment. Common European solutions are needed to achieve a real affordability and accessibility of medications.
药物及其价格是医疗保健的关键问题。尽管将以可承受的价格获取药品确定为欧洲卫生政策的一项关键目标,但这些目标似乎并未实现。因此,我们尝试对选定药品的全价可承受性进行评估。
该分析涉及2012年,于2013年至2015年期间在所有欧盟国家开展,这些国家根据加入欧盟的日期分为3组。最后,我们考虑了用于治疗精神分裂症和多发性硬化症的9种原研药。药品价格信息从药店收集。参与研究是自愿且匿名的,以避免被指责为广告宣传。为评估可承受性,使用了几个因素(例如最低收入和基尼系数)。由于某些国家数据不可用,分析的药品的确切数量有所不同。
欧盟成员国之间的药品价格差异显著。在德国(1451.17欧元)和克罗地亚(132.77欧元)之间,就22微克的β-1a干扰素而言,观察到近11倍的差异。总体而言,德国的价格最高。最便宜的药品在不同国家被发现,但从未在像保加利亚或罗马尼亚这样最贫穷的国家出现。工资差异也被观察到(保加利亚最低最低工资为138.00欧元,卢森堡最高为1801.00欧元)。然而,5毫克奥氮平的全价在保加利亚(64.53欧元)比例如比利时(37.26欧元)更高。
对于许多欧盟公民来说,分析的药物仍然难以承受。此外,例如由于平行贸易,药品的获取也受到损害。药品难以承受可能导致患者不遵医嘱,从而增加治疗的直接和间接成本。需要欧洲共同的解决方案来实现药品真正的可承受性和可及性。