Trebatická J, Dukát A, Ďuračková Z, Muchová J
Department of Child and Adolescent Psychiatry, Faculty of Medicine, Comenius University and Child University Hospital, Bratislava, Slovakia; Institute of Medical Chemistry, Biochemistry and Clinical Biochemistry, Faculty of Medicine, Comenius University, Bratislava, Slovakia.
Physiol Res. 2017 Jul 18;66(3):363-382. doi: 10.33549/physiolres.933430. Epub 2017 Feb 28.
Cardiovascular disease (CVD) and depressive disorders (DD) are two of the most prevalent health problems in the world. Although CVD and depression have different origin, they share some common pathophysiological characteristics and risk factors, such as the increased production of proinflammatory cytokines, endothelial dysfunction, blood flow abnormalities, decreased glucose metabolism, elevated plasma homocysteine levels, oxidative stress and disorder in vitamin D metabolism. Current findings confirm the common underlying factors for both pathologies, which are related to dramatic dietary changes in the mid-19th century. By changing dietary ratio of omega-6 to omega-3 fatty acids from 1:1 to 15-20:1 some changes in metabolism were induced, such as increased pro-inflammatory mediators and modulations of different signaling pathways following pathophysiological response related to both, cardiovascular diseases and depressive disorders.
心血管疾病（CVD）和抑郁症（DD）是世界上最普遍的两种健康问题。尽管心血管疾病和抑郁症有不同的起源，但它们具有一些共同的病理生理特征和风险因素，例如促炎细胞因子产生增加、内皮功能障碍、血流异常、葡萄糖代谢降低、血浆同型半胱氨酸水平升高、氧化应激以及维生素D代谢紊乱。目前的研究结果证实了这两种病症的共同潜在因素，这与19世纪中叶饮食的巨大变化有关。通过将omega-6与omega-3脂肪酸的饮食比例从1:1变为15 - 20:1，诱导了一些代谢变化，例如促炎介质增加以及与心血管疾病和抑郁症相关的病理生理反应后不同信号通路的调节。
