Pleissner Daniel, Dietz Donna, van Duuren Jozef Bernhard Johann Henri, Wittmann Christoph, Yang Xiaofeng, Lin Carol Sze Ki, Venus Joachim
Department of Bioengineering, Leibniz Institute for Agricultural Engineering and Bioeconomy Potsdam (ATB), Max-Eyth-Allee 100, 14469, Potsdam, Germany.
Institute of Systems Biotechnology, Saarland University, Saarbrücken, Germany.
Adv Biochem Eng Biotechnol. 2019;166:373-410. doi: 10.1007/10_2016_73.
Biotechnological processes are promising alternatives to petrochemical routes for overcoming the challenges of resource depletion in the future in a sustainable way. The strategies of white biotechnology allow the utilization of inexpensive and renewable resources for the production of a broad range of bio-based compounds. Renewable resources, such as agricultural residues or residues from food production, are produced in large amounts have been shown to be promising carbon and/or nitrogen sources. This chapter focuses on the biotechnological production of lactic acid, acrylic acid, succinic acid, muconic acid, and lactobionic acid from renewable residues, these products being used as monomers for bio-based material and/or as food supplements. These five acids have high economic values and the potential to overcome the "valley of death" between laboratory/pilot scale and commercial/industrial scale. This chapter also provides an overview of the production strategies, including microbial strain development, used to convert renewable resources into value-added products.
生物技术工艺有望成为石化路线的替代方案,以便以可持续的方式应对未来资源枯竭的挑战。白色生物技术策略允许利用廉价的可再生资源来生产各种各样的生物基化合物。诸如农业残留物或食品生产过程中的残渣等可再生资源产量巨大,已被证明是很有前景的碳源和/或氮源。本章重点介绍利用可再生残渣生物技术生产乳酸、丙烯酸、琥珀酸、粘康酸和乳糖酸,这些产品用作生物基材料的单体和/或食品补充剂。这五种酸具有很高的经济价值,并且有潜力克服实验室/中试规模与商业/工业规模之间的“死亡谷”。本章还概述了将可再生资源转化为增值产品的生产策略,包括微生物菌株开发。