Isolation and Synthesis of Misszrtine A: A Novel Indole Alkaloid From Marine Sponge-Associated sp. SCSIO XWS03F03.

A novel indole alkaloid, misszrtine A (), was isolated from marine sponge-derived fungus sp. SCSIO XWS03F03. The planar structure of was assigned by analysis of spectroscopic data, the absolute configuration of which was unambiguously determined by total synthesis. Compound represents the first example of -isopentenyl tryptophan methyl ester with a phenylpropanoic amide arm, which exhibited a potent antagonistic activity on HL60 (IC = 3.1 μM) and LNCaP (IC = 4.9 μM) cell lines. Bioactivity evaluation reveals that functional group on indole nitrogen of has a great effect on its cytotoxity, which provides a mean to probe the structure-activity relationships of .