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克罗恩病研究的微生物组基础。

A Microbiome Foundation for the Study of Crohn's Disease.

作者信息

Gevers Dirk, Kugathasan Subra, Knights Dan, Kostic Aleksandar D, Knight Rob, Xavier Ramnik J

机构信息

Janssen Human Microbiome Institute at Janssen Research and Development LLC, Cambridge, MA 02142, USA.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Emory University, Atlanta, GA 30322, USA.

出版信息

Cell Host Microbe. 2017 Mar 8;21(3):301-304. doi: 10.1016/j.chom.2017.02.012.

DOI:10.1016/j.chom.2017.02.012
PMID:28279336
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5684696/
Abstract

Our 2014 study published in Cell Host & Microbe, "The Treatment-Naive Microbiome in New-Onset Crohn's Disease," was designed to improve our understanding of the microbiome's role in Crohn's disease by studying a unique, well-suited cohort and sample set. This commentary provides a hindsight perspective of this original study as well as future outlook.

摘要

我们于2014年发表在《细胞宿主与微生物》杂志上的研究“初发性克罗恩病中未经治疗的微生物组”,旨在通过研究一个独特且非常合适的队列和样本集,增进我们对微生物组在克罗恩病中作用的理解。本评论提供了对这项原始研究的事后回顾视角以及未来展望。

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J Crohns Colitis. 2017 May 1;11(5):586-592. doi: 10.1093/ecco-jcc/jjw197.
2
Dog and human inflammatory bowel disease rely on overlapping yet distinct dysbiosis networks.犬和人类炎症性肠病依赖于重叠但不同的菌群失调网络。
Nat Microbiol. 2016 Oct 3;1:16177. doi: 10.1038/nmicrobiol.2016.177.
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Increased Intestinal Microbial Diversity Following Fecal Microbiota Transplant for Active Crohn's Disease.
胆汁酸谱和分类模型对炎症性肠病诊断的准确性。
Medicine (Baltimore). 2024 Jun 7;103(23):e38457. doi: 10.1097/MD.0000000000038457.
4
Cognitive behavioral and mindfulness with daily exercise intervention is associated with changes in intestinal microbial taxa and systemic inflammation in patients with Crohn's disease.认知行为和正念与日常锻炼干预相结合,与克罗恩病患者肠道微生物分类群和全身炎症的变化有关。
Gut Microbes. 2024 Jan-Dec;16(1):2337269. doi: 10.1080/19490976.2024.2337269. Epub 2024 Apr 9.
5
Microbiomic and Metabolomic Analyses Unveil the Protective Effect of Saffron in a Mouse Colitis Model.微生物组学和代谢组学分析揭示了藏红花在小鼠结肠炎模型中的保护作用。
Curr Issues Mol Biol. 2023 Jun 30;45(7):5558-5574. doi: 10.3390/cimb45070351.
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Ginsenoside Rg3 treats acute radiation proctitis through the TLR4/MyD88/NF-κB pathway and regulation of intestinal flora.人参皂苷 Rg3 通过 TLR4/MyD88/NF-κB 通路和肠道菌群调节治疗急性放射性直肠炎。
Front Cell Infect Microbiol. 2023 Jan 6;12:1028576. doi: 10.3389/fcimb.2022.1028576. eCollection 2022.
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A signature of and depletion, and a link with bacterial glutamate degradation in the Kenyan colorectal cancer patients.肯尼亚结直肠癌患者中[具体物质]和[具体物质]耗竭的特征,以及与细菌谷氨酸降解的联系。 (注:原文中“and”前后内容缺失,以上译文为根据格式要求,按照现有内容尽量合理翻译。)
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