Dayer J M, Evêquoz V, Zavadil-Grob C, Grynpas M D, Cheng P T, Schnyder J, Trechsel U, Fleisch H
Department of Medicine, Hôpital Cantonal Universitaire, Geneva, Switzerland.
Arthritis Rheum. 1987 Dec;30(12):1372-81. doi: 10.1002/art.1780301208.
Synthetic calcium pyrophosphate dihydrate crystals and, to a lesser extent, synthetic hydroxyapatite crystals increased the amount of interleukin-1/mononuclear cell factor released by human blood monocytes, as measured by collagenase and prostaglandin E2 production by rabbit chondrocytes, human dermal fibroblasts, and adherent rheumatoid synovial cells. The same crystals also directly induced collagenase and prostaglandin E2 secretion by rabbit chondrocytes, and potentiated the action of interleukin-1/mononuclear cell factor on chondrocytes. These mechanisms may be important in the pathogenesis of the destructive arthropathies associated with these crystals.
合成焦磷酸钙二水合物晶体，以及程度稍轻的合成羟基磷灰石晶体，会增加人血单核细胞释放的白细胞介素-1/单核细胞因子的量，这是通过兔软骨细胞、人皮肤成纤维细胞和贴壁类风湿滑膜细胞产生胶原酶和前列腺素E2来测定的。同样的晶体还直接诱导兔软骨细胞分泌胶原酶和前列腺素E2，并增强白细胞介素-1/单核细胞因子对软骨细胞的作用。这些机制可能在与这些晶体相关的破坏性关节病的发病机制中起重要作用。
