Department of Chemistry, University of Alberta , Edmonton, Alberta T6G 2R3, Canada.
Key Lab of Organic Optoelectronics & Molecular Engineering, Department of Chemistry, Tsinghua University , Beijing 100084, China.
ACS Appl Mater Interfaces. 2017 Apr 5;9(13):11368-11372. doi: 10.1021/acsami.7b02850. Epub 2017 Mar 24.
Daily repeated wound dressing changes will lead to additional trauma to newly formed tissue and prolonging the healing process. In this letter, we designed and fabricated an easily removable wound dressing material. To accomplish this, we first generated cross-linkable supramonomers through host-guest noncovalent interaction, followed by radical copolymerization of acrylamide with supramonomer as cross-linker to fabricate supramolecular hydrogels. Benefiting from the dynamic nature of the supramonomer, the supramolecular hydrogel is able to dissolve upon exposure to memantine, an FDA approved drug, making it easily removed from a wound, representing a promising candidate for the new generation of wound dressing.
每日重复的伤口换药会对新形成的组织造成额外的创伤，并延长愈合过程。在这封信中，我们设计并制造了一种易于去除的伤口敷料材料。为此，我们首先通过主客体非共价相互作用生成可交联的超单体，然后用丙烯酰胺与超单体作为交联剂进行自由基共聚，制备超分子水凝胶。得益于超单体的动态特性，超分子水凝胶在接触到已获 FDA 批准的药物美金刚后能够溶解，从而使其能够轻松从伤口上移除，这使其成为新一代伤口敷料的有前途的候选材料。
