Faculty of Biology, College of Science, University of Tehran, Tehran, Iran.
Faculty of Chemical Engineering, University of Tehran, Tehran, Iran.
J Control Release. 2017 May 10;253:97-109. doi: 10.1016/j.jconrel.2017.03.026. Epub 2017 Mar 18.
Today, the advanced drug delivery systems have been focused on targeted drug delivery fields. The novel drug delivery is involved with the improvement of the capacity of drug loading in drug carriers, cellular uptake of drug carriers, and the sustained release of drugs within target cells. In this review, six groups of therapeutic drug carriers including biomimetic hydrogels, biomimetic micelles, biomimetic liposomes, biomimetic dendrimers, biomimetic polymeric carriers and biomimetic nanostructures, are studied. The subject takes advantage of the biomimetic methods of productions or the biomimetic techniques for the surface modifications, similar to what accrues in natural cells. Moreover, the effects of these biomimetic approaches for promoting the drug efficiency in targeted drug delivery are visible. The study demonstrates that the fabrication of biomimetic nanocomposite drug carriers could noticeably promote the efficiency of drugs in targeted drug delivery systems.
如今，先进的药物输送系统已专注于靶向药物输送领域。新型药物输送涉及提高药物载体的载药量、药物载体的细胞摄取以及靶细胞内药物的持续释放能力。在这篇综述中，研究了包括仿生水凝胶、仿生胶束、仿生脂质体、仿生树状聚合物、仿生聚合物载体和仿生纳米结构在内的六组治疗性药物载体。该主题利用生产的仿生方法或表面修饰的仿生技术，类似于天然细胞中发生的情况。此外，这些仿生方法在促进靶向药物输送中药物效率方面的效果是显而易见的。研究表明，仿生纳米复合药物载体的制备可以显著提高靶向药物输送系统中药物的效率。
