• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Chicken homolog of the mos proto-oncogene.

作者信息

Schmidt M, Oskarsson M K, Dunn J K, Blair D G, Hughes S, Propst F, Vande Woude G F

机构信息

Bionetics Research, Inc., National Cancer Institute-Frederick Cancer Research Facility, Maryland 21701.

出版信息

Mol Cell Biol. 1988 Feb;8(2):923-9. doi: 10.1128/mcb.8.2.923-929.1988.

DOI:10.1128/mcb.8.2.923-929.1988
PMID:2832744
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC363224/
Abstract

We compared the sequence and properties of the chicken mos homolog with the previously characterized mouse and human c-mos genes. Sequence analysis revealed one major open reading frame of 1,047 base pairs encoding a protein of 349 amino acids. Both the nucleotide sequence and the deduced amino acid sequence showed 62% overall homology to mouse and human c-mos, but regions of higher conservation (approximately 70%) occurred in the putative ATP-binding and kinase domains. We detected mos transcripts by Northern (RNA) analyses in RNA prepared from chicken and quail ovaries and testes. Evidence for low levels of mos RNA expression in adult chicken heart, kidney, and spleen and in the entire embryo was obtained by S1 nuclease protection experiments. In contrast to the low transforming efficiency of human c-mos when linked to a mouse retroviral long terminal repeat element, chicken c-mos transformed NIH 3T3 cells as efficiently as mouse c-mos did. We also show that chicken primary embryo fibroblasts were morphologically altered when infected with an avian retroviral vector containing the chicken c-mos coding region.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/363224/09ad714face8/molcellb00062-0423-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/363224/83e6586aca6c/molcellb00062-0422-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/363224/09ad714face8/molcellb00062-0423-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/363224/83e6586aca6c/molcellb00062-0422-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fbee/363224/09ad714face8/molcellb00062-0423-a.jpg

相似文献

1
Chicken homolog of the mos proto-oncogene.
Mol Cell Biol. 1988 Feb;8(2):923-9. doi: 10.1128/mcb.8.2.923-929.1988.
2
Isolation and structural analysis of a biologically active chicken c-fos cDNA: identification of evolutionarily conserved domains in fos protein.具有生物活性的鸡c-fos cDNA的分离与结构分析：fos蛋白中进化保守结构域的鉴定
Oncogene. 1987;1(4):377-85.
3
Analysis of the transforming potential of the human homolog of mos.
Cell. 1986 Aug 29;46(5):785-94. doi: 10.1016/0092-8674(86)90354-5.
4
Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.mos原癌基因的非洲爪蟾同源物可转化哺乳动物成纤维细胞并诱导非洲爪蟾卵母细胞成熟。
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5805-9. doi: 10.1073/pnas.86.15.5805.
5
Cloning and expression of a chicken c-rel cDNA: unlike p59v-rel, p68c-rel is a cytoplasmic protein in chicken embryo fibroblasts.鸡c-rel cDNA的克隆与表达：与p59v-rel不同，p68c-rel在鸡胚成纤维细胞中是一种细胞质蛋白。
Oncogene. 1990 Mar;5(3):257-65.
6
Mouse c-mos oncogene activation is prevented by upstream sequences.小鼠c-mos癌基因的激活受到上游序列的抑制。
Proc Natl Acad Sci U S A. 1984 Dec;81(24):7817-21. doi: 10.1073/pnas.81.24.7817.
7
Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells.人类dbl原癌基因的分子克隆与特性分析：其过表达足以转化NIH/3T3细胞的证据
EMBO J. 1988 Aug;7(8):2465-73. doi: 10.1002/j.1460-2075.1988.tb03093.x.
8
Genomic organization and nucleotide sequence of the coding region of the chicken c-Rmil(B-raf-1) proto-oncogene.鸡c-Rmil（B-raf-1）原癌基因编码区的基因组结构和核苷酸序列。
Biochem Biophys Res Commun. 1993 Jun 30;193(3):1324-31. doi: 10.1006/bbrc.1993.1770.
9
Nucleotide sequence analysis of the chicken gene c-mil, the progenitor of the retroviral oncogene v-mil.鸡基因c-mil（逆转录病毒癌基因v-mil的前身）的核苷酸序列分析。
Virology. 1985 Jun;143(2):359-67. doi: 10.1016/0042-6822(85)90376-9.
10
The chicken c-fos gene: cloning and nucleotide sequence analysis.鸡c-fos基因：克隆与核苷酸序列分析。
J Virol. 1987 Dec;61(12):4012-8. doi: 10.1128/JVI.61.12.4012-4018.1987.

引用本文的文献

1
Search for the genes involved in oocyte maturation and early embryo development in the hen.寻找母鸡中参与卵母细胞成熟和早期胚胎发育的基因。
BMC Genomics. 2008 Feb 29;9:110. doi: 10.1186/1471-2164-9-110.
2
A phylogenetic hypothesis for passerine birds: taxonomic and biogeographic implications of an analysis of nuclear DNA sequence data.雀形目鸟类的系统发育假说：基于核DNA序列数据分析的分类学和生物地理学意义
Proc Biol Sci. 2002 Feb 7;269(1488):295-308. doi: 10.1098/rspb.2001.1883.
3
A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt.

本文引用的文献

1
Activation of the transforming potential of a normal cell sequence: a molecular model for oncogenesis.正常细胞序列转化潜能的激活：肿瘤发生的分子模型。
Science. 1981 May 22;212(4497):941-3. doi: 10.1126/science.7233190.
2
Rapid similarity searches of nucleic acid and protein data banks.核酸和蛋白质数据库的快速相似性搜索。
Proc Natl Acad Sci U S A. 1983 Feb;80(3):726-30. doi: 10.1073/pnas.80.3.726.
3
Direct evidence that oncogenic tyrosine kinases and cyclic AMP-dependent protein kinase have homologous ATP-binding sites.致癌性酪氨酸激酶和环磷酸腺苷依赖性蛋白激酶具有同源ATP结合位点的直接证据。
激酶mTOR在癌蛋白P3k和Akt诱导的细胞转化中的作用。
Proc Natl Acad Sci U S A. 2001 Jan 2;98(1):136-41. doi: 10.1073/pnas.98.1.136.
4
Mos activates myogenic differentiation by promoting heterodimerization of MyoD and E12 proteins.Mos通过促进MyoD和E12蛋白的异源二聚化来激活肌源性分化。
Mol Cell Biol. 1997 Feb;17(2):584-93. doi: 10.1128/MCB.17.2.584.
5
Microinjection of in vitro transcribed RNA and antisense oligonucleotides in mouse oocytes and early embryos to study the gain- and loss-of-function of genes.通过向小鼠卵母细胞和早期胚胎中显微注射体外转录的RNA和反义寡核苷酸来研究基因的功能获得和功能缺失。
Mol Biotechnol. 1996 Oct;6(2):191-9. doi: 10.1007/BF02740773.
6
Identification of a cis acting element responsible for muscle specific expression of the c-mos protooncogene.鉴定负责原癌基因c-mos肌肉特异性表达的顺式作用元件。
Nucleic Acids Res. 1993 Feb 11;21(3):695-702. doi: 10.1093/nar/21.3.695.
7
The murine cot proto-oncogene: genome structure and tissue-specific expression.小鼠原癌基因cot：基因组结构与组织特异性表达。
Jpn J Cancer Res. 1993 May;84(5):518-25. doi: 10.1111/j.1349-7006.1993.tb00170.x.
8
Xenopus homolog of the mos protooncogene transforms mammalian fibroblasts and induces maturation of Xenopus oocytes.mos原癌基因的非洲爪蟾同源物可转化哺乳动物成纤维细胞并诱导非洲爪蟾卵母细胞成熟。
Proc Natl Acad Sci U S A. 1989 Aug;86(15):5805-9. doi: 10.1073/pnas.86.15.5805.
9
Mouse Mos protooncogene product is present and functions during oogenesis.小鼠Mos原癌基因产物在卵子发生过程中存在并发挥作用。
Proc Natl Acad Sci U S A. 1989 Jul;86(14):5395-9. doi: 10.1073/pnas.86.14.5395.
10
Microinjection of antisense c-mos oligonucleotides prevents meiosis II in the maturing mouse egg.显微注射反义c-mos寡核苷酸可阻止成熟小鼠卵母细胞进入减数分裂II期。
Proc Natl Acad Sci U S A. 1989 Sep;86(18):7038-42. doi: 10.1073/pnas.86.18.7038.
Nature. 1984;310(5978):589-92. doi: 10.1038/310589a0.
4
The transforming protein of Moloney murine sarcoma virus is a soluble cytoplasmic protein.莫洛尼氏鼠肉瘤病毒的转化蛋白是一种可溶性细胞质蛋白。
Cell. 1983 May;33(1):161-72. doi: 10.1016/0092-8674(83)90345-8.
5
Mutagenesis of the region between env and src of the SR-A strain of Rous sarcoma virus for the purpose of constructing helper-independent vectors.为构建无辅助病毒载体，对劳氏肉瘤病毒SR - A株的env和src之间区域进行诱变。
Virology. 1984 Jul 15;136(1):89-99. doi: 10.1016/0042-6822(84)90250-2.
6
An integrated and simplified approach to cloning into plasmids and single-stranded phages.一种整合且简化的克隆到质粒和单链噬菌体中的方法。
Methods Enzymol. 1983;101:78-89. doi: 10.1016/0076-6879(83)01006-x.
7
The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers.pUC质粒，一种源自M13mp7的用于插入诱变和使用合成通用引物进行测序的系统。
Gene. 1982 Oct;19(3):259-68. doi: 10.1016/0378-1119(82)90015-4.
8
Human DNA sequence homologous to the transforming gene (mos) of Moloney murine sarcoma virus.与莫洛尼氏鼠肉瘤病毒转化基因（mos）同源的人类DNA序列。
Proc Natl Acad Sci U S A. 1982 Jul;79(13):4078-82. doi: 10.1073/pnas.79.13.4078.
9
Viral src gene products are related to the catalytic chain of mammalian cAMP-dependent protein kinase.病毒src基因产物与哺乳动物环磷酸腺苷（cAMP）依赖性蛋白激酶的催化链相关。
Proc Natl Acad Sci U S A. 1982 May;79(9):2836-9. doi: 10.1073/pnas.79.9.2836.
10
Nucleotide sequence and formation of the transforming gene of a mouse sarcoma virus.小鼠肉瘤病毒转化基因的核苷酸序列与形成
Nature. 1981 Jan 22;289(5795):258-62. doi: 10.1038/289258a0.