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1
Hypothyroidism in rats does not lower mitochondrial ADP/O and H+/O ratios.大鼠甲状腺功能减退不会降低线粒体的ADP/O和H+/O比率。
Biochem J. 1988 Mar 1;250(2):477-84. doi: 10.1042/bj2500477.
2
The influence of nanomolar calcium ions and physiological levels of thyroid hormone on oxidative phosphorylation in rat liver mitochondria. A possible signal amplification control mechanism.纳摩尔钙离子和甲状腺激素生理水平对大鼠肝脏线粒体氧化磷酸化的影响。一种可能的信号放大控制机制。
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3
The rapid alteration by tri-iodo-L-thyronine in vivo of both the ADP/O ratio and the apparent H+/O ratio in hypothyroid-rat liver mitochondria.三碘-L-甲状腺原氨酸在体内对甲状腺功能减退大鼠肝线粒体中ADP/O比值和表观H⁺/O比值的快速改变。
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4
Alterations of oxidative phosphorylation reactions in mitochondria isolated from hypothyroid rat liver.
Eur J Biochem. 1984 May 15;141(1):9-13. doi: 10.1111/j.1432-1033.1984.tb08148.x.
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Rapid thyroid-hormone effect on mitochondrial and cytosolic ATP/ADP ratios in the intact liver cell.甲状腺激素对完整肝细胞中线粒体和胞质ATP/ADP比值的快速作用
Biochem J. 1985 Apr 1;227(1):149-53. doi: 10.1042/bj2270149.
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The rapid response of isolated mitochondrial particles to 0.1 nM-tri-iodothyronine correlates with the ADP-ribosylation of a single inner-membrane protein.分离出的线粒体颗粒对0.1纳摩尔三碘甲状腺原氨酸的快速反应与单个内膜蛋白的ADP核糖基化相关。
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Control of adenine nucleotide metabolism in hepatic mitochondria from rats with ethanol-induced fatty liver.乙醇诱导脂肪肝大鼠肝脏线粒体中腺嘌呤核苷酸代谢的调控
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The influence of hypothyroidism on the transport of phosphate and on the lipid composition in rat-liver mitochondria.
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ADP delivery from adenylate kinase in the mitochondrial intermembrane space to oxidative phosphorylation increases in the presence of macromolecules.在大分子存在的情况下，线粒体外膜间隙中腺苷酸激酶向氧化磷酸化的ADP传递增加。
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Oxidative phosphorylation in brown adipose tissue mitochondria from rats kept under normal environmental conditions.处于正常环境条件下的大鼠棕色脂肪组织线粒体中的氧化磷酸化。
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Comparative effects of 3,5-diiodo-L-thyronine and 3,5,3'-triiodo-L-thyronine on mitochondrial damage and cGAS/STING-driven inflammation in liver of hypothyroid rats.3,5-二碘-L-甲状腺素和 3,5,3'-三碘-L-甲状腺素对甲状腺功能减退症大鼠肝脏线粒体损伤和 cGAS/STING 驱动的炎症的比较作用。
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Hypothyroidism leads to a decreased expression of mitochondrial F0F1-ATP synthase in rat liver.甲状腺功能减退导致大鼠肝脏中线粒体F0F1 - ATP合酶的表达降低。
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Selective labelling and inactivation of creatine kinase isoenzymes by the thyroid hormone derivative N-bromoacetyl-3,3',5-tri-iodo-L-thyronine.甲状腺激素衍生物N-溴乙酰基-3,3',5-三碘-L-甲状腺原氨酸对肌酸激酶同工酶的选择性标记与失活作用
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Thyroid hormones and the creatine kinase system in cardiac cells.心脏细胞中的甲状腺激素与肌酸激酶系统
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9
Control of respiration in non-phosphorylating mitochondria is shared between the proton leak and the respiratory chain.非磷酸化线粒体中的呼吸控制由质子泄漏和呼吸链共同承担。
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Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-L-thyronine.3,5-二碘-L-甲状腺原氨酸对肝脏耗氧量的快速刺激作用。
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本文引用的文献

1
Respiration-driven proton translocation in rat liver mitochondria.呼吸驱动的大鼠肝线粒体质子转运
Biochem J. 1967 Dec;105(3):1147-62. doi: 10.1042/bj1051147.
2
The influence of thyroxine on oxidative phosphorylation in mitochondria from thyroidectomized rats.甲状腺素对甲状腺切除大鼠线粒体氧化磷酸化的影响。
J Biol Chem. 1962 Mar;237:897-903.
3
Respiratory enzymes in oxidative phosphorylation. I. Kinetics of oxygen utilization.氧化磷酸化中的呼吸酶。I. 氧气利用动力学
J Biol Chem. 1955 Nov;217(1):383-93.
4
Rapid effect of triiodothyronine on the mitochondrial pathway in rat liver in vivo.三碘甲状腺原氨酸对大鼠肝脏线粒体途径的体内快速作用。
Science. 1980 Oct 17;210(4467):340-2. doi: 10.1126/science.7423197.
5
Effect of funiculosin and antimycin A on the redox-driven H+-pumps in mitochondria: on the nature of "leaks'.真菌毒素和抗霉素A对线粒体中氧化还原驱动的H⁺泵的影响：关于“泄漏”的本质
Eur J Biochem. 1981 Jul;117(2):389-94. doi: 10.1111/j.1432-1033.1981.tb06350.x.
6
Mitochondrial binding of triiodothyronine (T3). Demonstration by electron-microscopic radioautography of dispersed liver cells.三碘甲状腺原氨酸（T3）的线粒体结合。通过分散肝细胞的电子显微镜放射自显影进行证明。
Cell Tissue Res. 1984;236(2):321-5. doi: 10.1007/BF00214233.
7
Alterations of oxidative phosphorylation reactions in mitochondria isolated from hypothyroid rat liver.
Eur J Biochem. 1984 May 15;141(1):9-13. doi: 10.1111/j.1432-1033.1984.tb08148.x.
8
Proton translocation coupled to mitochondrial electron transport.质子转运与线粒体电子传递相偶联。
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9
Localization of 3,5,3'-L-triiodothyronine receptor in rat kidney mitochondrial membranes.3,5,3'-L-三碘甲状腺原氨酸受体在大鼠肾脏线粒体膜中的定位
Biochem Biophys Res Commun. 1982 Jun 15;106(3):920-6. doi: 10.1016/0006-291x(82)91798-3.
10
Molecular slipping in redox and ATPase H+ pumps.氧化还原与ATP酶H⁺泵中的分子滑动
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大鼠甲状腺功能减退不会降低线粒体的ADP/O和H+/O比率。

Hypothyroidism in rats does not lower mitochondrial ADP/O and H+/O ratios.

作者信息

Hafner R P, Brand M D

机构信息

Department of Biochemistry, University of Cambridge, U.K.

出版信息

Biochem J. 1988 Mar 1;250(2):477-84. doi: 10.1042/bj2500477.

DOI:10.1042/bj2500477
PMID:2833245
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1148881/
Abstract

We investigated reports that mitochondria isolated from hypothyroid rats have decreased ADP/O and H+/O ratios. We observed no decrease in the H+/O ratio in mitochondria from hypothyroid rats, in the presence of either 2% (w/v) fatty-acid-free bovine serum albumin or 100 nM free Ca2+. The ADP/O ratio in mitochondria isolated from hypothyroid rats in the presence of 2% fatty-acid-free bovine serum albumin was measured. Under normal experimental conditions we found no decrease in the ADP/O ratio, relative to that measured for littermate controls. At the low concentrations of mitochondrial protein used in the previously reported studies, the ADP/O ratio of mitochondria from hypothyroid rats was decreased, whereas that for control rats was only slightly decreased. The difference between the ADP/O ratios measured for mitochondria form hypothyroid rats and from control rats under these conditions was eliminated by inhibition of endogenous adenylate kinase. We suggest that the lowering of the apparent ADP/O ratio in mitochondria from hypothyroid rats at low concentrations of mitochondrial protein is an experimental artefact resulting from the breakdown of ADP to AMP.

摘要

我们对有关从甲状腺功能减退大鼠分离出的线粒体的ADP/O和H⁺/O比率降低的报道进行了研究。在存在2%（w/v）无脂肪酸牛血清白蛋白或100 nM游离Ca²⁺的情况下，我们未观察到甲状腺功能减退大鼠线粒体的H⁺/O比率降低。测定了在存在2%无脂肪酸牛血清白蛋白的情况下从甲状腺功能减退大鼠分离出的线粒体的ADP/O比率。在正常实验条件下，相对于同窝对照所测的ADP/O比率，我们未发现其降低。在先前报道的研究中所使用的低线粒体蛋白浓度下，甲状腺功能减退大鼠线粒体的ADP/O比率降低，而对照大鼠的仅略有降低。通过抑制内源性腺苷酸激酶，消除了在这些条件下甲状腺功能减退大鼠和对照大鼠线粒体所测ADP/O比率之间的差异。我们认为，在低线粒体蛋白浓度下甲状腺功能减退大鼠线粒体中表观ADP/O比率的降低是由ADP分解为AMP导致的实验假象。