恶病质素/肿瘤坏死因子可刺激人滑膜细胞和真皮成纤维细胞产生胶原酶和前列腺素E2。
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.
作者信息
Dayer J M, Beutler B, Cerami A
出版信息
J Exp Med. 1985 Dec 1;162(6):2163-8. doi: 10.1084/jem.162.6.2163.
Abstract
Cachectin/TNF (tumor necrosis factor), an endotoxin-induced murine macrophage hormone implicated in the pathogenesis of cachexia and shock, has been found capable of stimulating collagenase and prostaglandin E2 (PGE2) production by isolated human synovial cells and dermal fibroblasts. This bioactivity associated with cachectin is comparable to that observed with the monokine interleukin 1 (IL-1), previously suggested as the major mediator of proteolysis. The ability of cachectin/TNF to stimulate collagenase and PGE2 production suggests that it may play a role in tissue destruction and remodelling, as these processes occur in inflammatory diseases.
摘要
恶病质素/肿瘤坏死因子（TNF）是一种由内毒素诱导产生的鼠巨噬细胞激素，与恶病质和休克的发病机制有关，现已发现它能够刺激分离出的人滑膜细胞和皮肤成纤维细胞产生胶原酶和前列腺素E2（PGE2）。与恶病质素相关的这种生物活性与之前被认为是蛋白水解主要介质的单核因子白细胞介素1（IL-1）所观察到的生物活性相当。恶病质素/TNF刺激胶原酶和PGE2产生的能力表明，在炎症性疾病中出现的组织破坏和重塑过程中，它可能发挥作用。
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本文引用的文献
1
Arachidonic acid, prostaglandin E2 and F2 alpha influence rates of protein turnover in skeletal and cardiac muscle.花生四烯酸、前列腺素E2和F2α影响骨骼肌和心肌中的蛋白质周转率。
J Biol Chem. 1982 Feb 25;257(4):1632-8.
2
Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever.白细胞致热原（白细胞介素-1）对肌肉蛋白质降解和前列腺素E2释放的刺激作用。发热期间肌肉蛋白质降解增加的一种机制。
N Engl J Med. 1983 Mar 10;308(10):553-8. doi: 10.1056/NEJM198303103081002.
3
Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.人肿瘤坏死因子：前体结构、表达及其与淋巴毒素的同源性。
Nature. 1984;312(5996):724-9. doi: 10.1038/312724a0.
4
Interleukin-1.白细胞介素-1
Rev Infect Dis. 1984 Jan-Feb;6(1):51-95. doi: 10.1093/clinids/6.1.51.
5
Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte-activating factor (interleukin 1).部分纯化的淋巴细胞激活因子（白细胞介素1）对类风湿性滑膜细胞胶原酶和前列腺素产生的刺激作用。
Proc Natl Acad Sci U S A. 1981 Apr;78(4):2474-7. doi: 10.1073/pnas.78.4.2474.
6
Purification of a factor from human blood monocyte-macrophages which stimulates the production of collagenase and prostaglandin E2 by cells cultured from rheumatoid synovial tissues.从人血单核细胞-巨噬细胞中纯化一种因子，该因子可刺激类风湿性滑膜组织培养细胞产生胶原酶和前列腺素E2。
FEBS Lett. 1981 Feb 23;124(2):253. doi: 10.1016/0014-5793(81)80149-4.
7
Cloning and expression of murine interleukin-1 cDNA in Escherichia coli.小鼠白细胞介素-1 cDNA在大肠杆菌中的克隆与表达。
Nature. 1984;312(5993):458-62. doi: 10.1038/312458a0.
8
Induction of human interleukin 1 mRNA measured by collagenase- and prostaglandin E2-stimulating activity in rheumatoid synovial cells.通过类风湿性滑膜细胞中胶原酶和前列腺素E2刺激活性来测定人白细胞介素1信使核糖核酸的诱导情况。
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10
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