Zimmermann Andreas, Kainz Katharina, Andryushkova Aleksandra, Hofer Sebastian, Madeo Frank, Carmona-Gutierrez Didac
Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria.
Institute of Molecular Biosciences, NAWI Graz, University of Graz, Graz, Austria. ; BioTechMed Graz, Graz, Austria.
Microb Cell. 2016 Dec 5;3(12):579-581. doi: 10.15698/mic2016.12.544.
The recent announcement of the 2016 Nobel Prize in Physiology or Medicine, awarded to Yoshinori Ohsumi for the discoveries of mechanisms governing autophagy, underscores the importance of intracellular degradation and recycling. At the same time, it further cements yeast, in which this field decisively developed, as a prolific model organism. Here we provide a quick historical overview that mirrors both the importance of autophagy as a conserved and essential process for cellular life and death as well as the crucial role of yeast in its mechanistic characterization.
2016年诺贝尔生理学或医学奖近日揭晓，授予大隅良典，以表彰他在细胞自噬机制研究方面的发现，这凸显了细胞内降解与循环利用的重要性。与此同时，这进一步巩固了酵母在该领域作为多产模式生物的地位，细胞自噬领域正是在酵母中取得了决定性进展。在此，我们提供一份简要的历史概述，既反映出自噬作为细胞生死过程中一个保守且必不可少的过程的重要性，也体现出酵母在其机制表征方面所发挥的关键作用。
