College of Food Science and Technology, Nanjing Agricultural University , Nanjing, Jiangsu 210095, People's Republic of China.
Nutrition and Food Branch of China Association of Gerontology and Geriatrics , Beijing 100050, People's Republic of China.
J Agric Food Chem. 2017 Apr 19;65(15):3160-3166. doi: 10.1021/acs.jafc.7b00489. Epub 2017 Apr 6.
The gut microbiota has the ability to modulate host energy homeostasis, which may regulate metabolic disorders. Functional oligosaccharide may positively regulate the intestinal microbiota. Therefore, effects of α-galactooligosaccharides (α-GOS) from chickpea on high-fat-diet (HFD)-induced metabolic syndrome and gut bacterial dysbiosis were investigated. After 6 weeks of intervention, HFD led to significant increases in levels of blood glucose, total cholesterol, triglyceride, glycated serum protein, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol of mice compared to normal-chow-fed mice. Meanwhile, all of the α-GOS-treated groups significantly decreased above parameters compared to the HFD group. HFD could significantly decrease the content of all bacteria, especially Bacteroides (9.82 ± 0.09 versus 10.3 ± 0.10; p < 0.05) and Lactobacillus (6.67 ± 0.18 versus 7.30 ± 0.24; p < 0.05), and a decrease in the production of short-chain fatty acids was also observed. Treatment with α-GOS significantly increased the number of Bifidobacterium (6.07 ± 0.23 of the low-dose treatment versus 5.65 ± 0.20 of the HFD group) and Lactobacillus (7.22 ± 0.16 of the low-dose treatment). It also significantly promoted the secretion of propionic and butyric acids. These results indicate that α-GOS from chickpeas may affect the metabolic disorders and gut bacterial ecosystem in a positive way.
肠道微生物群具有调节宿主能量平衡的能力，这可能调节代谢紊乱。功能性低聚糖可能对肠道微生物群产生积极的调节作用。因此，研究了鹰嘴豆来源的α-半乳糖寡糖（α-GOS）对高脂肪饮食（HFD）诱导的代谢综合征和肠道细菌失调的影响。干预 6 周后，与正常饮食喂养的小鼠相比，HFD 导致小鼠的血糖、总胆固醇、甘油三酯、糖化血清蛋白、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平显著升高。同时，与 HFD 组相比，所有α-GOS 处理组均显著降低了上述参数。HFD 可显著降低所有细菌的含量，尤其是拟杆菌（9.82 ± 0.09 与 10.3 ± 0.10 相比；p < 0.05）和乳杆菌（6.67 ± 0.18 与 7.30 ± 0.24 相比；p < 0.05），并且短链脂肪酸的产生也观察到减少。α-GOS 的治疗显著增加了双歧杆菌的数量（低剂量治疗的 6.07 ± 0.23 与 HFD 组的 5.65 ± 0.20 相比）和乳杆菌（低剂量治疗的 7.22 ± 0.16）。它还显著促进丙酸和丁酸的分泌。这些结果表明，鹰嘴豆来源的α-GOS 可能以积极的方式影响代谢紊乱和肠道细菌生态系统。
