Dong Y H, Zou Z Y, Yang Z P, Wang Z H, Jing J, Luo J Y, Zhang X, Luo C Y, Wang H, Zhao H P, Pan D H, Ma J
School of Public Health &Institute of Child and Adolescent Health, Peking University, Beijing, China.
Department of Maternal and Child Health, School of Public Health, Sun Yat-sen University, Guangzhou, China.
J Hum Hypertens. 2017 Nov;31(11):737-743. doi: 10.1038/jhh.2017.22. Epub 2017 Apr 6.
This study aims to examine the relationship between high birth weight (HBW) and blood pressure and assess whether HBW leads to increased hypertension during childhood and adolescence. All the participants aged 6-18 years with HBW were selected from a cross-sectional study from seven provinces in China. Nine thousand nine hundred and sixty-two children were randomly sampled with matched data. Basic information of students was collected with a standardized student and guardian questionnaire. High blood pressure was defined according to sex-, age- and height-specific references. Multi-variance logistic regression was used to estimate the odds ratio (OR) of high blood pressure and HBW after adjustment for confounding factors. The overall mean of systolic BP and diastolic BP in HBW group were significantly higher than normal group in both genders and urban/rural area. Corresponding overall prevalence of high BP, elevated SBP and elevated DBP in HBW group were also higher than normal group in both genders, respectively (boys: 19.41% vs 16.16%; 10.12% vs 8.16%; 14.86% vs 12.71%; girls: 14.95% vs 12.66%; 8.19% vs 6.56%; 11.13% vs 9.86%). In addition, birth weight was positively associated with high BP, elevated SBP and elevated DBP in children and adolescents of both sexes (boys: OR 1.25, 1.27, 1.20; girls: OR 1.21, 1.27, 1.15). However, the positive association was attenuated and even reversed after adjustment for potential confounding variables. In this study, HBW may lead to higher childhood blood pressure, but no association between HBW and childhood hypertension was observed.
本研究旨在探讨高出生体重（HBW）与血压之间的关系，并评估HBW是否会导致儿童期和青春期高血压发病率增加。所有6至18岁的高出生体重参与者均选自中国七个省份的一项横断面研究。随机抽取了9962名儿童，并获取了匹配数据。通过标准化的学生和监护人问卷收集学生的基本信息。高血压根据性别、年龄和身高特异性参考标准进行定义。采用多变量逻辑回归分析在调整混杂因素后估计高血压与HBW的比值比（OR）。高出生体重组的收缩压和舒张压总体均值在性别和城乡地区均显著高于正常组。高出生体重组相应的高血压、收缩压升高和舒张压升高的总体患病率在男女中也分别高于正常组（男孩：19.41%对16.16%；10.12%对8.16%；14.86%对12.71%；女孩：14.95%对12.66%；8.19%对6.56%；11.13%对9.86%）。此外，出生体重与男女儿童及青少年的高血压、收缩压升高和舒张压升高呈正相关（男孩：OR 1.25、1.27、1.20；女孩：OR 1.21、1.27、1.15）。然而，在调整潜在混杂变量后，这种正相关减弱甚至逆转。在本研究中，高出生体重可能导致儿童期血压升高，但未观察到高出生体重与儿童期高血压之间的关联。
