Loker Hydrocarbon Research Institute and Department of Chemistry, University of Southern California, Los Angeles, CA 90089-1661, USA.
Chem Soc Rev. 2017 May 22;46(10):3060-3094. doi: 10.1039/c7cs00082k.
Benzodiazines (diazonaphthalenes with both nitrogens in the same ring) - cinnolines (1,2-benzodiazine), quinazolines (1,3-benzodiazine), phthalazines (2,3-benzodiazine) and quinoxalines (1,4-benzodiazine) - are important class of compounds with broad biological properties and wide application in pharmaceutical as well as agrochemical arenas. These diazaheterocycles are present in a wide variety of bioactive natural products as well as synthetic molecules that are good drug candidates constituting key structural units responsible for their pronounced therapeutic activities. Their rapidly growing uses and applications in medicinal and agrochemical arenas prompt the researchers for further studies on this important group of compounds. In this review, we hope to provide a brief overview of the important general methodologies and recent developments towards their synthesis and open the door for further progress in this area.
苯并二氮杂环（同一环中两个氮原子的二氮萘）- 吖啶（1,2-苯并二氮杂环）、喹唑啉（1,3-苯并二氮杂环）、酞嗪（2,3-苯并二氮杂环）和喹喔啉（1,4-苯并二氮杂环）- 是一类具有广泛生物特性和广泛应用于药物和农业化学领域的重要化合物。这些氮杂杂环存在于各种具有生物活性的天然产物以及合成分子中，这些分子是良好的药物候选物，构成了负责其显著治疗活性的关键结构单元。它们在医药和农业化学领域的快速应用促使研究人员进一步研究这一重要化合物群体。在这篇综述中，我们希望提供对其合成的重要一般方法和最新进展的简要概述，并为该领域的进一步发展开辟道路。
