Warnecke Daniela, Schild N B, Klose S, Joos H, Brenner R E, Kessler O, Skaer N, Walker R, Freutel M, Ignatius A, Dürselen L
Institute of Orthopaedic Research and Biomechanics, Centre for Trauma Research Ulm, Ulm University Medical Centre, Germany.
Division for Biochemistry of Joint and Connective Tissue Diseases, Department of Orthopaedics, Ulm University Medical Centre, Germany.
Tribol Int. 2017 May;109:586-592. doi: 10.1016/j.triboint.2017.01.038.
The menisci protect the articular cartilage by reducing contact pressure in the knee. To restore their function after injury, a new silk fibroin replacement scaffold was developed. To elucidate its tribological properties, friction of the implant was tested against cartilage and glass, where the latter is typically used in tribological cartilage studies. The silk scaffold exhibited a friction coefficient against cartilage of 0.056, which is higher than meniscus against cartilage but in range of the requirements for meniscal replacements. Further, meniscus friction against glass was lower than cartilage against glass, which correlated with the surface lubricin content. Concluding, the tribological properties of the new material suggest a possible long-term chondroprotective function. In contrast, glass always produced high, non-physiological friction coefficients.
半月板通过降低膝关节内的接触压力来保护关节软骨。为了在损伤后恢复其功能，研发了一种新型丝素蛋白替代支架。为阐明其摩擦学特性，测试了该植入物与软骨及玻璃之间的摩擦力，后者常用于软骨摩擦学研究。丝素支架与软骨之间的摩擦系数为0.056，高于半月板与软骨之间的摩擦系数，但在半月板置换的要求范围内。此外，半月板与玻璃之间的摩擦力低于软骨与玻璃之间的摩擦力，这与表面润滑素含量相关。总之，新材料的摩擦学特性表明其可能具有长期软骨保护功能。相比之下，玻璃总是产生较高的、非生理性的摩擦系数。
