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年龄对脾脏和淋巴结微观结构的影响。

Influence of ageing on the microarchitecture of the spleen and lymph nodes.

机构信息

The Roslin Institute and Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Easter Bush Campus, Roslin, Midlothian, EH25 9RG, UK.

出版信息

Biogerontology. 2017 Oct;18(5):723-738. doi: 10.1007/s10522-017-9707-7. Epub 2017 May 13.

DOI:10.1007/s10522-017-9707-7
PMID:28501894
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5597693/
Abstract

The elderly have a decreased response to vaccination and an increased susceptibility to infectious diseases. The spleen and lymph nodes are important secondary lymphoid organs where immune cells can rapidly respond to pathogenic material in the blood and lymph in order to mount long-term adaptive immune responses to those pathogens. In aged mice and humans structural changes occur to both the spleen and lymph nodes. These structural changes affect the functioning of the immune cells within, which may ultimate result in less effective or decreased immune responses. This review describes our current understanding of the structural changes that occur to the spleen and lymph nodes of elderly mice. However, where data are available, we also discuss whether similar changes occur in tissues from elderly humans. A particular focus is made on how these structural changes are considered to impact on the functioning of the immune cells within. The world's population is currently living longer than ever before. The increased incidence and severity of infectious diseases in the elderly has the potential to have a significant impact on the health care system if solutions are not identified. A thorough understanding of the molecular causes of these ageing-related structural changes to the spleen and lymph nodes may help to identify novel treatments that could repair them, and in doing so, improve immune responses and vaccine efficacy in the elderly.

摘要

老年人对疫苗的反应减弱，对传染病的易感性增加。脾脏和淋巴结是重要的次级淋巴器官，免疫细胞可以在血液和淋巴中迅速对病原体物质作出反应，从而对这些病原体产生长期的适应性免疫反应。在老年小鼠和人类中，脾脏和淋巴结都会发生结构变化。这些结构变化会影响其中免疫细胞的功能，这可能最终导致免疫反应效果降低或减弱。这篇综述描述了我们目前对老年小鼠脾脏和淋巴结发生的结构变化的理解。然而，在有数据可用的情况下，我们还讨论了类似的变化是否发生在老年人类的组织中。特别关注的是这些结构变化如何被认为会影响其中免疫细胞的功能。目前，世界人口的寿命比以往任何时候都长。如果不找到解决办法，老年人传染病发病率和严重程度的增加有可能对医疗保健系统产生重大影响。深入了解这些与年龄相关的脾脏和淋巴结结构变化的分子原因，可能有助于确定新的治疗方法来修复这些变化，并在此过程中改善老年人的免疫反应和疫苗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/36e6d9c6928c/10522_2017_9707_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/bd52b82b7238/10522_2017_9707_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/873a4cb4aee2/10522_2017_9707_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/05720add27ab/10522_2017_9707_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/36e6d9c6928c/10522_2017_9707_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/bd52b82b7238/10522_2017_9707_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/873a4cb4aee2/10522_2017_9707_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/05720add27ab/10522_2017_9707_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4dab/5597693/36e6d9c6928c/10522_2017_9707_Fig4_HTML.jpg

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