Kim Minkyung, Kim Minjoo, Lee Ayoung, Yoo Hye Jin, Her Jung Soo, Jee Sun Ha, Lee Jong Ho
Research Center for Silver Science, Institute of Symbiotic Life-TECH, Yonsei University, Seoul, 03722 Korea.
National Leading Research Laboratory of Clinical Nutrigenetics/Nutrigenomics, Department of Food and Nutrition, College of Human Ecology, Yonsei University, Seoul, 03722 Korea.
Nutr Metab (Lond). 2017 May 8;14:32. doi: 10.1186/s12986-017-0186-2. eCollection 2017.
No intervention follow-up study has examined the association between plasma n-6 polyunsaturated fatty acids (PUFAs) and lipoprotein-associated phospholipase A (Lp-PLA), which is a risk factor for cardiovascular disease (CVD). We aimed to determine whether the administration of linoleic acid (LA, 18:2n-6) in soy oil affected Lp-PLA activity in healthy adults.
Self-reported healthy participants ( = 150) were randomly assigned to three groups: a low LA group, in which 10 mL soy oil was replaced with one apple; a medium LA group, in which the typical food intake was maintained; and a high LA group, in which 1/3 cup of cooked refined rice was replaced with 9.9 g of soy oil capsules daily. Plasma fatty acids and Lp-PLA activity were measured along with other CVD risk factors.
After 8 weeks of treatment, plasma LA levels decreased in the low LA group and increased in the high LA group. The high LA group showed greater increases in apolipoprotein B (apoB) and oxidized low-density lipoprotein (ox-LDL) than those in the low LA group. Plasma LA levels and Lp-PLA activities demonstrated greater increases in the high LA group than those in the medium and low LA groups. Changes in plasma LA positively and independently correlated with changes in Lp-PLA activity, which was negatively correlated with changes in collagen-epinephrine closure time (CEPI-CT).
An increase in plasma LA following intake of soy oil was independently associated with Lp-PLA activity, which was also related to apoB, ox-LDL and CEPI-CT.
ClinicalTrail.gov Identifier: NCT02753907, registered 25 April 2016 (retrospectively registered).
尚无干预随访研究探讨血浆n-6多不饱和脂肪酸（PUFAs）与脂蛋白相关磷脂酶A（Lp-PLA）之间的关联，而Lp-PLA是心血管疾病（CVD）的一个危险因素。我们旨在确定在健康成年人中给予大豆油中的亚油酸（LA，18:2n-6）是否会影响Lp-PLA活性。
自我报告健康的参与者（n = 150）被随机分为三组：低LA组，用一个苹果替代10毫升大豆油；中LA组，维持典型食物摄入量；高LA组，每天用9.9克大豆油胶囊替代1/3杯煮熟的精制大米。测量血浆脂肪酸和Lp-PLA活性以及其他CVD危险因素。
治疗8周后，低LA组血浆LA水平下降，高LA组血浆LA水平上升。高LA组载脂蛋白B（apoB）和氧化低密度脂蛋白（ox-LDL）的升高幅度大于低LA组。高LA组血浆LA水平和Lp-PLA活性的升高幅度大于中、低LA组。血浆LA的变化与Lp-PLA活性的变化呈正相关且独立相关，而Lp-PLA活性与胶原-肾上腺素封闭时间（CEPI-CT）的变化呈负相关。
摄入大豆油后血浆LA的升高与Lp-PLA活性独立相关，Lp-PLA活性还与apoB、ox-LDL和CEPI-CT有关。
ClinicalTrail.gov标识符：NCT02753907，于2016年4月25日注册（追溯注册）。
