el-Mekki A, Deverajan L V, Soufi S, Strannegard O, al-Nakib W
Department of Microbiology, Faculty of Medicine, University of Kuwait, Safat.
Epidemiol Infect. 1988 Dec;101(3):495-501. doi: 10.1017/s0950268800029381.
IgM antibodies specific for cytomegalovirus (CMV) were demonstrated in 15 (2.6%) of 575 umbilical cord sera obtained from newborns in Kuwait. Some 93% and 50% of these CMV-IgM positive cord sera displayed markedly raised (more than normal mean +2 S.D.) content of total IgM and IgA respectively. In contrast, only 0.2 and 1.8% of the CMV-IgM negative cord sera had elevated total IgM and IgA, respectively. Rheumatoid factor (RF) was demonstrable, at concentrations of 30 IU/ml or more, in 67% of the CMV-IgM positive as compared with 3.2% of the CMV-IgM negative sera whereas interferon alpha was found in the serum of only one of these infants. These results indicate that raised total immunoglobulin, in particular IgM, concentrations and the detection of RF in cord blood are useful non-specific markers for the identification of congenital CMV infection.
在从科威特新生儿采集的575份脐带血清中，有15份（2.6%）检测出了针对巨细胞病毒（CMV）的IgM抗体。这些CMV-IgM阳性脐带血清中，约93%和50%的总IgM和IgA含量显著升高（超过正常均值+2个标准差）。相比之下，CMV-IgM阴性脐带血清中，只有0.2%和1.8%的总IgM和IgA含量升高。类风湿因子（RF）浓度在30 IU/ml及以上时，CMV-IgM阳性血清中有67%可检测到，而CMV-IgM阴性血清中只有3.2%可检测到，并且在这些婴儿中只有一名婴儿的血清中发现了α干扰素。这些结果表明，脐带血中总免疫球蛋白尤其是IgM浓度升高以及RF的检测，是用于识别先天性CMV感染的有用非特异性标志物。
