Shaikh Sana, Channa Naseem Aslam, Talpur Farha Naz, Younis Muhammad, Tabassum Naila
Institute of Biochemistry, University of Sindh, Sindh, Jamshoro, Pakistan.
National Centre of Excellence in Analytical Chemistry, University of Sindh, Jamshoro, 76080, Pakistan.
Lipids Health Dis. 2017 May 18;16(1):92. doi: 10.1186/s12944-017-0481-y.
Breast cancer is a disease with diverse clinical symptoms, molecular profiles, and its nature to response its therapeutic treatments. Radiotherapy (RT), along with surgery and chemotherapy is a part of treatment in breast cancer. The aim of present study was to investigate pre and post treatment effects of radiotherapy in serum fatty acids and its lipids profile in patients with breast cancer.
In this comparative as well as follow up study, Serum fatty acids were performed by gas chromatography to investigate fatty acids and Microlab for analysis of lipid profile.
Among serum free and total fatty acids the major saturated fatty acids (SFAs) in serum lipids of breast cancer patients (pre and post treated) were stearic acid (18:0) and palmitic acid (16:0). These fatty acids contributed about 35-50% of total fatty acids. The decreased concentrations of linoleic acid (C18:2) and arachidonic acid (C20:4) with a lower ratio of C18:2/C18:1 was found in pretreated breast cancer patients as compared to controls. The n-3/n-6 ratio of breast cancer patients was decreased before treatment but it was 35% increased after treatment. In addition, plasma activity of D6 desaturase was increased in the breast cancer patients, while the activity of D5 desaturase was decreased. Increased levels of SFAs, monounsaturated fatty acids (MUFAs) and decreased polyunsaturated fatty acids (PUFAs) levels in breast cancer patients (pre and post treated) as compared to controls. Serum total cholesterol (TC) (224.4 mg/dL) and low density lipoprotein cholesterol (LDL-C) (142.9 mg/dL) were significantly increased in pretreated breast cancer patients but after the radiotherapy treatment, the TC (150.2 mg/dL) and LDL-C (89.8 mg/dL) were decreased.
It seems that RT would have played a potential role in the treatment of BC. After RT the serum levels of PUFAs, TC, and LDL-C are improved. Our study reinforces the important role of RT in the management of BC. The level of PUFAs, TC, and LDL-C can be used as the biomarkers for early diagnosis in individuals with risk of breast cancer.
乳腺癌是一种具有多样临床症状、分子特征及其对治疗反应特性的疾病。放射治疗（RT）与手术和化疗一样，是乳腺癌治疗的一部分。本研究的目的是调查放射治疗对乳腺癌患者血清脂肪酸及其脂质谱的治疗前后影响。
在这项对比及随访研究中，通过气相色谱法检测血清脂肪酸以研究脂肪酸，并使用Microlab分析脂质谱。
在血清游离脂肪酸和总脂肪酸中，乳腺癌患者（治疗前后）血清脂质中的主要饱和脂肪酸（SFA）为硬脂酸（18:0）和棕榈酸（16:0）。这些脂肪酸约占总脂肪酸的35 - 50%。与对照组相比，治疗前乳腺癌患者中发现亚油酸（C18:2）和花生四烯酸（C20:4）浓度降低，且C18:2/C18:1比值较低。乳腺癌患者治疗前n - 3/n - 6比值降低，但治疗后升高了35%。此外，乳腺癌患者中D6去饱和酶的血浆活性升高，而D5去饱和酶的活性降低。与对照组相比，乳腺癌患者（治疗前后）的饱和脂肪酸（SFA）、单不饱和脂肪酸（MUFA）水平升高，多不饱和脂肪酸（PUFA）水平降低。治疗前乳腺癌患者血清总胆固醇（TC）（224.4mg/dL）和低密度脂蛋白胆固醇（LDL - C）（142.9mg/dL）显著升高，但放射治疗后，TC（150.2mg/dL）和LDL - C（89.8mg/dL）降低。
似乎放射治疗在乳腺癌治疗中发挥了潜在作用。放射治疗后，多不饱和脂肪酸、总胆固醇和低密度脂蛋白胆固醇的血清水平得到改善。我们的研究强化了放射治疗在乳腺癌管理中的重要作用。多不饱和脂肪酸、总胆固醇和低密度脂蛋白胆固醇的水平可作为乳腺癌风险个体早期诊断的生物标志物。
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