From the Department of Pathology and Immunology, Washington University in St. Louis, MO.
Circ Res. 2017 May 26;120(11):1699-1701. doi: 10.1161/CIRCRESAHA.117.311021.
A major obstacle to intravital visualization of inflammatory processes within large arteries is the motion of vessels that occurs near the beating heart. In this issue, Quintar et al. apply ILTIS, the German word for the European polecat that serves as an acronym for Intravital Live-cell Triggered Imaging System, to capture the most sophisticated images of inflammatory cell dynamics in the arterial vasculature to date, by timing data acquisition to a consistent point in every heartbeat. The authors show that patrolling nonclassical monocytes scan endothelium in plaque-prone areas, much as they have been described to elsewhere. The inability of these monocytes to patrol arteries leads to heightened endothelial damage within the artery. In this way, nonclassical monocytes safeguard against plaque development and progression.
在跳动的心脏附近，大动脉内部炎症过程的活体可视化存在一个主要障碍，即血管的运动。在本期中，Quintar 等人应用了 ILTIS，这是德语中欧鼬的缩写，代表活体活细胞触发成像系统，通过将数据采集与每个心跳的一致点同步，来捕获迄今为止动脉脉管系统中炎症细胞动力学的最复杂图像。作者表明，巡逻的非经典单核细胞扫描斑块易损区的内皮细胞，就像在其他地方描述的那样。这些单核细胞不能巡逻动脉，导致动脉内皮细胞损伤加剧。通过这种方式，非经典单核细胞可以防止斑块的形成和发展。
